Genotype and allele analyses of guanosine triphosphate cyclohydrolase 1 single-nucleotide polymorphism in patients with fibromyalgia syndrome (FM; n = 409) and healthy controls (n = 422). Logistic regression models were used to calculate OR.
| Position* | Genotype/Allele | Healthy Controls† n (%) | Patients with FM† n (%) | p†† | Crude OR (95% CI) | Age- and Sex-adjusted OR (95% CI) |
|---|---|---|---|---|---|---|
| rs841 (C>T) | TT | 77 (18.3) | 73 (17.9) | 0.89 | 1.00 (reference) | 1.00 (reference) |
| CT | 191 (45.3) | 180 (44.0) | 0.93 (0.69–1.26) | 0.93 (0.68–1.27) | ||
| CC | 154 (36.5) | 156 (38.1) | 0.94 (0.63–1.38) | 0.89 (0.60–1.33) | ||
| T | 345 (40.9) | 326 (39.9) | 0.67 | 1.00 (reference) | 1.00 (reference) | |
| C | 499 (59.1) | 492 (60.2) | 0.96 (0.79–1.17) | 0.94 (0.77–1.15) | ||
| rs752688 (C>T) | TT | 77 (18.3) | 76 (18.6) | 0.97 | 1.00 (reference) | 1.00 (reference) |
| CT | 195 (46.2) | 191 (46.7) | 1.04 (0.76–1.40) | 1.00 (0.73–1.37) | ||
| CC | 150 (35.6) | 142 (34.7) | 1.04 (0.71–1.54) | 0.97 (0.65–1.45) | ||
| T | 349 (41.4) | 343 (41.9) | 0.81 | 1.00 (reference) | 1.00 (reference) | |
| C | 495 (58.7) | 475 (58.1) | 1.02 (0.84–1.25) | 0.99 (0.81–1.21) | ||
| rs4411417 (T>C) | CC | 73 (17.3) | 75 (18.4) | 0.69 | 1.00 (reference) | 1.00 (reference) |
| TC | 188 (44.6) | 189 (46.3) | 1.12 (0.83–1.52) | 1.11 (0.82–1.51) | ||
| TT | 161 (38.2) | 144 (35.3) | 1.15 (0.78–1.70) | 1.09 (0.73–1.63) | ||
| C | 334 (39.6) | 339 (41.5) | 0.41 | 1.00 (reference) | 1.00 (reference) | |
| T | 510 (60.4) | 477 (58.5) | 1.09 (0.89–1.32) | 1.06 (0.87–1.29) | ||
| rs3783641 (T>A) | AA | 11 (2.6) | 16 (3.9) | 0.26 | 1.00 (reference) | 1.00 (reference) |
| TA | 115 (27.3) | 95 (23.2) | 0.82 (0.60–1.12) | 0.80 (0.58–1.11) | ||
| TT | 295 (70.1) | 298 (72.9) | 1.44 (0.66–3.16) | 1.65 (0.74–3.67) | ||
| A | 137 (16.3) | 127 (15.5) | 0.68 | 1.00 (reference) | 1.0 (reference) | |
| T | 705 (83.7) | 691 (84.5) | 0.95 (0.73–1.23) | 0.96 (0.74–1.26) |