Time, yrs | p (T0 vs T3) | ||||
---|---|---|---|---|---|
T0 | T1 | T2 | T3 | ||
ILO group | |||||
Loss of capillaries | 1.71 ± 0.70 | 1.86 ± 0.52 | 1.93 ± 0.46 | 2.00 ± 0.38 | 0.05 |
Giant capillaries | 1.14 ± 0.83 | 1.29 ± 0.59 | 1.14 ± 0.64 | 0.93 ± 0.59 | 0.05 |
Microhemorrhages | 0.86 ± 0.52 | 0.93 ± 0.46 | 0.93 ± 0.46 | 0.86 ± 0.52 | NS |
Ramifications | 1.50 ± 0.91 | 1.64 ± 0.72 | 1.79 ± 0.56 | 1.71 ± 0.88 | 0.05 |
ILO+BOS group | |||||
Loss of capillaries | 1.79 ± 0.89 | 1.79 ± 0.89 | 1.71 ± 0.88 | 1.43 ± 0.65 | 0.02 |
Giant capillaries | 0.93 ± 0.73 | 1.00 ± 0.78 | 1.00 ± 0.78 | 0.71 ± 0.83 | NS |
Microhemorrhages | 0.57 ± 0.65 | 0.50 ± 0.65 | 0.43 ± 0.65 | 0.36 ± 0.63 | NS |
Ramifications | 1.21 ± 0.80 | 1.43 ± 0.51 | 1.79 ± 0.70 | 2.07 ± 0.83 | 0.003 |
ILO: iloprost; BOS: bosentan; T0: baseline; T1: 1 year; T2: 2 years; T3: 3 years; NS: nonsignificant.