Table 2.

Estimates of haplotype frequencies in patients with fibromyalgia syndrome (FM; n = 408) and healthy controls (n = 421). Statistical package PHASE v2.1.1 was used to construct haplotype structures and estimate frequencies; missing data were excluded (n = 4). Data are percentage ± SE.

Combined AllelesAll SubjectsHealthy ControlsPatients with FMp††
CCTT53.1 ± 0.353.8 ± 0.352.3 ± 0.30.01
TTCT25.6 ± 0.327.3 ± 0.423.9 ± 0.3
TTCA12.3 ± 0.311.8 ± 0.412.7 ± 0.3
CCTA2.7 ± 0.23.4 ± 0.31.9 ± 0.2
CTCT2.0 ± 0.10.2 ± 0.14.0 ± 0.1
TCTT1.4 ± 0.10.9 ± 0.21.9 ± 0.2
CTTT1.2 + 0.11.3 ± 0.11.1 ± 0.1
TCTA0.6 ± 0.10.3 ± 0.20.8 ± 0.2
CCCT0.4 ± 0.060.1 ± 0.030.6 ± 0.1
TTTA0.3 ± 0.050.5 ± 0.090.0 ± 0.02
TTTT0.2 ± 0.050.1 ± 0.080.4 ± 0.05
TCCT0.1 ± 0.020.0 ± 0.020.3 ± 0.03
CTCA0.1 ± 0.010.1 ± 0.010.0 ± 0.01
  • Among 13 constructed haplotypes, 7 haplotypes with ≥ 1.0% frequency are presented.

  • Combined alleles are in their physical order along the chromosome: rs841, rs752688, rs4411417, rs3783641.

  • †† p value for permutation test of the null hypothesis that cases and controls are random draws from a common set of haplotype frequencies (no. permutations = 10,000).