Genotype and minor allele frequencies of SNP within IL6 gene in patients with SSc and healthy controls from Germany.

					Genotype, n (%)			Allele Test
CHR	SNP	Locus	1/2	Subgroup (n)	1/1	1/2	2/2	MAF, %	p^*	p_FDR^**	OR (95% CI)^***
7	rs2069827	IL6	G/T	Controls (289)	226 (78.20)	57 (19.72)	6 (2.08)	11.94
				SSc (579)	466 (80.48)	107 (18.48)	6 (1.04)	10.28	0.29	0.44	0.84 (0.62–1.16)
				lcSSc (338)	267 (78.99)	67 (19.82)	4 (1.18)	11.09	0.64	0.90	0.92 (0.65–1.30)
				dcSSc (241)	199 (82.57)	40 (16.60)	2 (0.83)	9.13	0.14	0.21	0.74 (0.50–1.11)
				ACA+ (224)	182 (81.25)	39 (17.41)	3 (1.34)	10.04	0.34	0.51	0.82 (0.55–1.23)
				ATA+ (190)	154 (81.05)	35 (18.42)	1 (0.53)	9.74	0.29	0.43	0.80 (0.52–1.21)
7	rs1800795	IL6	G/C	Controls (290)	83 (28.62)	148 (51.03)	59 (20.34)	45.86
				SSc (568)	205 (36.09)	262 (46.13)	101 (17.78)	40.85	0.05	0.14	0.82 (0.67–1.00)
				lcSSc (331)	112 (33.84)	158 (47.73)	61 (18.43)	42.30	0.21	0.62	0.87 (0.69–1.08)
				dcSSc (237)	93 (39.24)	104 (43.88)	40 (16.88)	38.82	0.02	0.06	0.75 (0.59–0.96)
				ACA+ (219)	79 (36.07)	105 (47.95)	35 (15.98)	39.95	0.06	0.18	0.79 (0.61–1.01)
				ATA+ (189)	75 (39.68)	81 (42.86)	33 (17.46)	38.89	0.03	0.10	0.75 (0.58–0.98)
7	rs2069840	IL6	C/G	Controls (287)	125 (43.55)	136 (47.39)	26 (9.06)	32.75
				SSc (572)	254 (44.41)	251 (43.88)	67 (11.71)	33.65	0.71	0.71	1.04 (0.84–1.29)
				lcSSc (334)	149 (44.61)	149 (44.61)	36 (10.78)	33.08	0.90	0.90	1.02 (0.80–1.29)
				dcSSc (238)	105 (44.12)	102 (42.86)	31 (13.03)	34.45	0.56	0.56	1.08 (0.83–1.40)
				ACA+ (220)	90 (40.91)	109 (49.55)	21 (9.55)	34.32	0.60	0.60	1.07 (0.82–1.40)
				ATA+ (189)	84 (44.44)	78 (41.27)	27 (14.29)	34.92	0.49	0.49	1.10 (0.84–1.45)

↵* Values calculated for the allelic model.
↵** Multiple testing false discovery rate correction.
↵*** For the minor allele. SNP: single-nucleotide polymorphism; IL: interleukin; SSc: systemic sclerosis; MAF: minor allele frequency.