Genotype, n (%) | Allele Test | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
CHR | SNP | Locus | 1/2 | Subgroup (n) | 1/1 | 1/2 | 2/2 | MAF, % | p* | pFDR** | OR (95% CI)*** |
7 | rs2069827 | IL6 | G/T | Controls (596) | 529 (88.76) | 63 (10.57) | 4 (0.67) | 5.96 | |||
SSc (374) | 329 (87.97) | 45 (12.03) | 0 (0.00) | 6.02 | 0.96 | 0.96 | 1.01 (0.69–1.49) | ||||
lcSSc (254) | 229 (90.16) | 25 (9.84) | 0 (0.00) | 4.92 | 0.40 | 0.60 | 0.82 (0.51–1.31) | ||||
dcSSc (120) | 100 (83.33) | 20 (16.67) | 0 (0.00) | 8.33 | 0.17 | 0.51 | 1.44 (0.86–2.41) | ||||
ACA+ (90) | 79 (87.78) | 11 (12.22) | 0 (0.00) | 6.11 | 0.93 | 0.93 | 1.03 (0.53–1.98) | ||||
ATA+ (102) | 89 (87.25) | 13 (12.75) | 0 (0.00) | 6.37 | 0.82 | 0.45 | 1.08 (0.58–1.98) | ||||
7 | rs1800795 | IL6 | G/C | Controls (585) | 246 (42.05) | 258 (44.10) | 81 (13.85) | 35.90 | |||
SSc (375) | 152 (40.53) | 179 (47.73) | 44 (11.73) | 35.60 | 0.89 | 0.96 | 0.99 (0.82–1.20) | ||||
lcSSc (254) | 102 (40.16) | 125 (49.21) | 27 (10.63) | 35.24 | 0.80 | 0.80 | 0.97 (0.78–1.21) | ||||
dcSSc (121) | 50 (41.32) | 54 (44.63) | 17 (14.05) | 36.36 | 0.89 | 0.89 | 1.02 (0.77–1.36) | ||||
ACA+ (92) | 36 (39.13) | 49 (53.26) | 7 (7.61) | 34.24 | 0.66 | 0.93 | 0.93 (0.67–1.29) | ||||
ATA+ (102) | 48 (47.06) | 43 (42.16) | 11 (10.78) | 31.86 | 0.27 | 0.45 | 0.84 (0.61–1.15) | ||||
7 | rs2069840 | IL6 | C/G | Controls (578) | 204 (35.29) | 277 (47.92) | 97 (16.78) | 40.74 | |||
SSc (367) | 149 (40.60) | 181 (49.32) | 37 (10.08) | 34.74 | 0.01 | 0.03 | 0.77 (0.64–0.94) | ||||
lcSSc (248) | 106 (42.74) | 118 (47.58) | 24 (9.68) | 33.47 | 0.01 | 0.02 | 0.73 (0.59–0.91) | ||||
dcSSc (119) | 43 (36.13) | 63 (52.94) | 13 (10.92) | 37.39 | 0.34 | 0.51 | 0.87 (0.65–1.16) | ||||
ACA+ (88) | 35 (39.77) | 46 (52.27) | 7 (7.95) | 34.09 | 0.09 | 0.28 | 0.75 (0.54–1.05) | ||||
ATA+ (103) | 40 (38.83) | 50 (48.54) | 13 (12.62) | 36.89 | 0.30 | 0.82 | 0.85 (0.63–1.16) |