Change from baseline in modified Total Sharp Score (mTSS) over time.
| ΔmTSS, mean (SEM) | Year 1 | Year 4 | Year 5 |
|---|---|---|---|
| PBO-randomized, n = 79* | 2.39 (0.45) | 5.26 (0.91) | 5.51 (0.95) |
| RTX-randomized, n = 105* | 1.08 (0.24) | 2.86 (0.60) | 3.21 (0.64) |
↵* At Year 1, n = 75 (PBO-randomized); n = 102 (RTX-randomized). PBO: placebo; RTX: rituximab.