Genotype and minor allele frequencies of SNP located within IL6 gene in patients with SSc and healthy controls of the different study cohorts.
| Genotype, n (%) | Allele Test | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| SNP | 1/2 | Subgroup (n) | 1/1 | 1/2 | 2/2 | MAF, % | p* | pBFN** | OR (95% CI)*** |
| rs2069827 | G/T | Controls (3189) | 2687 (84.26) | 473 (14.83) | 29 (0.91) | 8.33 | |||
| SSc (2739) | 2339 (85.40) | 379 (13.84) | 21 (0.77) | 7.69 | 0.018 | 0.162 | 0.85 (0.74–0.97) | ||
| lcSSc (1848) | 1574 (85.17) | 257 (13.91) | 17 (0.92) | 7.87 | 0.083 | 0.87 (0.75–1.02) | |||
| dcSSc (891) | 765 (85.86) | 122 (13.69) | 4 (0.45) | 7.30 | 0.024 | 0.216 | 0.79 (0.64–0.97) | ||
| ACA+ (1049) | 902 (85.99) | 137 (13.06) | 10 (0.95) | 7.48 | 0.051 | 0.83 (0.69–1.00) | |||
| ATA+ (611) | 521 (85.27) | 86 (14.08) | 4 (0.65) | 7.69 | 0.141 | 0.84 (0.66–1.06) | |||
| FLA+ (715) | 604 (84.48) | 106 (14.83) | 5 (0.70) | 8.11 | 0.297 | 0.89 (0.72–1.11) | |||
| rs1800795 | G/C | Controls (3179) | 1215 (38.22) | 1492 (46.93) | 472 (14.85) | 38.31 | |||
| SSc (2749) | 1077 (39.18) | 1250 (45.47) | 422 (15.35) | 38.09 | 0.252 | 0.96 (0.89–1.03) | |||
| lcSSc (1850) | 705 (38.11) | 843 (45.57) | 302 (16.32) | 39.11 | 0.985 | 1.00 (0.92–1.09) | |||
| dcSSc (899) | 372 (41.38) | 407 (45.27) | 120 (13.35) | 35.98 | 0.008 | 0.072 | 0.86 (0.77–0.96) | ||
| ACA+ (1059) | 401 (37.87) | 494 (46.65) | 164 (15.49) | 38.81 | 0.829 | 0.99 (0.89–1.10) | |||
| ATA+ (611) | 244 (39.93) | 281 (45.99) | 86 (14.08) | 37.07 | 0.141 | 0.91 (0.80–1.03) | |||
| FLA+ (716) | 251 (35.06) | 352 (49.16) | 113 (15.78) | 38.09 | 0.575 | 1.00 (0.91–1.17) | |||
| rs2069840 | C/G | Controls (3162) | 1300 (41.11) | 1459 (46.14) | 403 (12.75) | 35.82 | |||
| SSc (2725) | 1176 (43.16) | 1252 (45.94) | 297 (10.90) | 33.87 | 0.060 | 0.93 (0.86–1.00) | |||
| lcSSc (1840) | 819 (44.51) | 835 (45.38) | 186 (10.11) | 32.80 | 0.004 | 0.036 | 0.88 (0.81–0.96) | ||
| dcSSc (885) | 357 (40.34) | 417 (47.12) | 111 (12.54) | 36.10 | 0.497 | 1.04 (0.93–1.16) | |||
| ACA+ (1044) | 444 (42.53) | 500 (47.89) | 100 (9.58) | 33.52 | 0.125 | 0.92 (0.83–1.02) | |||
| ATA+ (612) | 260 (42.48) | 281 (45.92) | 71 (11.60) | 34.56 | 0.499 | 0.96 (0.84–1.09) | |||
| FLA+ (705) | 310 (43.97) | 325 (46.10) | 70 (9.93) | 32.98 | 0.124 | 0.91 (0.80–1.03) | |||
↵* Values calculated for the allelic model and Mantel-Haenszel test under fixed effect.
↵** Multiple testing Bonferroni (BFN) correction.
↵*** For the minor allele. SSc: systemic sclerosis; lcSSc: limited cutaneous SSc; dcSSc: diffuse cutaneous SSc; ACA: anticentromere antibodies; ATA: antitopoisomerase antibodies; FLA: fibrotic lung; MAF: minor allele frequency; SNP: single-nucleotide polymorphism.