Genotype, n (%) | Allele Test | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
CHR | SNP | Locus | 1/2 | Subgroup (n) | 1/1 | 1/2 | 2/2 | MAF, % | p* | pFDR** | OR (95% CI)*** |
7 | rs2069827 | IL6 | G/T | Controls (260) | 213 (81.92) | 46 (17.69) | 1 (0.38) | 9.23 | |||
SSc (100) | 83 (83.00) | 16 (16.00) | 1 (1.00) | 9.00 | 0.92 | 0.97 | 0.97 (0.55–1.72) | ||||
lcSSc (67) | 52 (77.61) | 14 (20.90) | 1 (1.49) | 11.94 | 0.35 | 0.35 | 1.33 (0.73–2.43) | ||||
dcSSc (33) | 31 (93.94) | 2 (6.06) | 0 (0.00) | 3.03 | 0.09 | 0.15 | 0.31 (0.07–1.30) | ||||
ACA+ (54) | 44 (81.48) | 9 (16.67) | 1 (1.85) | 10.19 | 0.76 | 0.82 | 1.12 (0.56–2.23) | ||||
ATA+ (14) | 13 (92.86) | 1 (7.14) | 0 (0.00) | 3.57 | 0.31 | 0.31 | 0.36 (0.05–2.74) | ||||
7 | rs1800795 | IL6 | G/C | Controls (246) | 72 (29.27) | 126 (51.22) | 48 (19.51) | 45.12 | |||
SSc (99) | 27 (27.27) | 55 (55.56) | 17 (17.17) | 44.95 | 0.97 | 0.97 | 0.99 (0.71–1.38) | ||||
lcSSc (67) | 15 (22.39) | 37 (55.22) | 15 (22.39) | 50.00 | 0.32 | 0.35 | 1.22 (0.83–1.78) | ||||
dcSSc (32) | 12 (37.50) | 18 (56.25) | 2 (6.25) | 34.38 | 0.10 | 0.15 | 0.64 (0.37–1.10) | ||||
ACA+ (54) | 16 (29.63) | 26 (48.15) | 12 (22.22) | 46.30 | 0.82 | 0.82 | 1.05 (0.69–1.59) | ||||
ATA+ (14) | 7 (50.00) | 5 (35.71) | 2 (14.29) | 32.14 | 0.18 | 0.31 | 0.58 (0.26–1.30) | ||||
7 | rs2069840 | IL6 | C/G | Controls (260) | 118 (45.38) | 113 (43.46) | 29 (11.15) | 32.88 | |||
SSc (98) | 45 (45.92) | 43 (43.88) | 10 (10.20) | 32.14 | 0.85 | 0.97 | 0.97 (0.68–1.37) | ||||
lcSSc (65) | 35 (53.85) | 24 (36.92) | 6 (9.23) | 27.69 | 0.26 | 0.35 | 0.78 (0.51–1.20) | ||||
dcSSc (33) | 10 (30.30) | 19 (57.58) | 4 (12.12) | 40.91 | 0.19 | 0.19 | 1.41 (0.84–2.39) | ||||
ACA+ (53) | 27 (50.94) | 20 (37.74) | 6 (11.32) | 30.19 | 0.59 | 0.82 | 0.88 (0.56–1.39) | ||||
ATA+ (14) | 4 (28.57) | 8 (57.14) | 2 (14.29) | 42.86 | 0.28 | 0.31 | 1.53 (0.71–3.31) |