Vitamin D receptor single-nucleotide polymorphism rs2228570 (Fok1) and shared-epitope (SE) status in patients with rheumatoid arthritis (RA) and controls. Values reported are n (% of RA or control); OR (95% CI).
| Model | RA, n = 348 | Control, n = 330 | |
|---|---|---|---|
| Genotypic model | |||
| SE-negative | |||
| CC (FF) | 9 (18) | 24 (20) | Chi-square 0.39, p = NS |
| CT (Ff) | 29 (57) | 61 (52) | |
| TT (ff) | 13 (25) | 33 (28) | |
| SE-positive | |||
| CC (FF) | 67 (22) | 60 (22) | Chi-square 11.3, p = 0.003 |
| CT (Ff) | 147 (49) | 100 (36) | |
| TT (ff) | 88 (29) | 114 (42) | |
| Dominant model | |||
| SE negative | |||
| CC, CT | 38 (75) | 85 (72) | OR 1.19 (95% CI 0.54–2.60), p = NS |
| TT | 13 (25) | 33 (28) | |
| SE positive | |||
| CC, CT | 214 (71) | 160 (58) | OR 1.74 (95% CI 1.22–2.48), p = 0.002 |
| TT | 88 (29) | 114 (42) |
NS: nonsignificant.