Celecoxib, 50 mg bid, n = 100 | Celecoxib, 400/200 mg, n = 99 | Celecoxib, 800/400 mg, n = 96 | Indomethacin 50 mg tid, n = 102 | |
---|---|---|---|---|
Baseline | ||||
n | 100 | 99 | 96 | 102 |
Mean (SD) | 3.03 (0.67) | 2.73 (0.62) | 2.84 (0.69) | 2.83 (0.76) |
Range | 2.0–4.0 | 2.0–4.0 | 2.0–4.0 | 2.0–4.0 |
Day 2 (change from baseline) | ||||
n | 97 | 96 | 94 | 98 |
Mean (SD) | −1.14 (1.10) | −1.23 (0.97) | −1.51 (1.11) | −1.62 (0.97) |
Range | −4.0 to 1.0 | −3.0 to 1.0 | −4.0 to 1.0 | −3.0 to 1.0 |
Vs celecoxib 50 mg bid | ||||
LS mean difference (SE) | — | −0.24 (0.14) | −0.46 (0.14) | — |
95% CI | — | −0.52 to 0.04 | −0.74 to −0.18 | — |
p | — | 0.0947 | 0.0014 | — |
Vs indomethacin 50 mg tid | ||||
LS mean difference (SE) | 0.57 (0.14) | 0.33 (0.14) | 0.11 (0.14) | — |
95% CI | 0.29 to 0.84 | 0.05 to 0.60 | −0.17 to 0.39 | — |
p | < 0.0001 | 0.0196 | 0.4331 | — |
Bid: twice daily; LS: least squares; SE: standard error; tid: 3 times daily.