Groups | Patient | Age/Sex | Disease Duration, yrs | RF/ACPA | HLA-DRB1 Allele | HLA-Present | Anti-TNF Agent | DAS28 After MTX Treatment | DAS28 After 20 Weeks | Response to Anti-TNF Agent |
---|---|---|---|---|---|---|---|---|---|---|
MTX responders, n = 8 | 1 | 58 M | 3 | Pos/pos | 01:01/04:01 | Yes | None | 0.14 | NA | NA |
2 | 71 F | 6 | Pos/pos | 13:01/03:01 | No | None | 2.52 | NA | NA | |
3 | 64 M | 7 | Pos/pos | 01:02/03:01 | Yes | None | 2.05 | NA | NA | |
4 | 66 F | 2 | Pos/neg | 03:01/16:01 | No | None | 1.89 | NA | NA | |
5 | 47 F | 12 | Pos/pos | 04:04/04:01 | Yes | None | 2.37 | NA | NA | |
6 | 40 F | 2 | Pos/pos | 04:04/13:01 | Yes | None | 2.24 | NA | NA | |
7 | 37 F | 7 | Pos/pos | 04:01/07:01 | Yes | None | 2.25 | NA | NA | |
8 | 55 F | 14 | Neg/neg | 14:02/16:01 | Yes | None | 1.54 | NA | NA | |
MTX nonresponders, n = 17 | 9 | 47 F | 7 | Pos/neg | 03:01/13:01 | No | Infliximab | 5.23 | 2.52 | Yes |
10 | 65 F | 11 | Pos/pos | 01:01/07:01 | Yes | Infliximab | 7.23 | 2.05 | Yes | |
11 | 56 M | 12 | Pos/pos | 13:01/15:01 | No | Infliximab | 7.43 | 3.46 | Yes | |
12 | 41 F | 1 | Pos/pos | 03:01/07:01 | No | Infliximab | 7.96 | 3.56 | Yes | |
13 | 67 M | 6 | Neg/pos | 04:01/11:01 | Yes | Infliximab | 6.02 | 3.56 | Yes | |
14 | 64 F | 1 | Neg/pos | 11:01/13:01 | No | Infliximab | 7.24 | 2.78 | Yes | |
15 | 61 F | 10 | Neg/neg | 03:01/11:01 | No | Infliximab | 5.3 | 2.43 | Yes | |
16 | 59 F | 6 | Neg/neg | 01:01/14:01 | Yes | Infliximab | 5.97 | 2.79 | Yes | |
17 | 29 F | 8 | Neg/pos | 01:01/14:01 | Yes | Infliximab | 5.39 | 2.32 | Yes | |
18 | 46 M | 2 | Pos/pos | 04:01/07:01 | Yes | Infliximab | 6.57 | 6.2 | No | |
19 | 38 F | 9 | Pos/pos | 01:02/03:01 | Yes | Infliximab | 6.06 | 5.71 | No | |
20 | 39 M | 2 | Pos/pos | 04:01/04:04 | Yes | Infliximab | 8.76 | 7.77 | No | |
21 | 62 F | 3 | Pos/pos | 01:01/16:01 | Yes | Infliximab | 6.74 | 6.88 | No | |
22 | 51 F | 1 | Pos/pos | 10:01/12:01 | Yes | Infliximab | 6.5 | 5.78 | No | |
23 | 53 F | 2 | Neg/pos | 01:02/07:01 | Yes | Infliximab | 6 | 5.9 | No | |
24 | 55 F | 6 | Neg/pos | 04:01/10:01 | Yes | Infliximab | 7.03 | 6.13 | No | |
25 | 34 F | 3 | Pos/pos | 04:01/04:01 | Yes | Infliximab | 4.66 | 3.55 | No |
MTX: methotrexate; TNF: tumor necrosis factor; RF: rheumatoid factor; ACPA: anticitrullinated protein antibodies; HLA-SE: shared epitope of HLA-DRB1: DAS28: 28-joint count Disease Activity Score; NA: not applicable.