The association between genetic factors and ACPA was tested in 172 RA patients by comparing (Fisher exact test) the distribution of patients positive and negative for anti-VCP antibodies among carriers and noncarriers for each genetic variant.
| Anti-VCP1 | Anti-VCP2 | Anti-CCP | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Factor | Neg | Pos | OR (95% CI) | Fisher p | Neg | Pos | OR (95% CI) | Fisher p | Neg | Pos | OR (95% CI) | Fisher p | |
| OR for developing anti-VCP antibodies in the presence of susceptible genes (HLA-SE, PTPN22, TRAF1.C5, PAD4) | |||||||||||||
| HLA-SE | No | 21 | 12 | 1.646 | 0.23 | 15 | 18 | 1.409 | 0.42 | 11 | 22 | 1.862 | 0.17 |
| Yes | 73 | 66 | (0.734–3.687) | 51 | 88 | (0.642–3.092) | 29 | 108 | (0.810–4.278) | ||||
| PTPN22 | No | 66 | 48 | 1.473 | 0.25 | 44 | 70 | 1.028 | 1 | 30 | 84 | 1.036 | 0.45 |
| Yes | 28 | 30 | (0.780–2.780) | 22 | 36 | (0.536–1.974) | 12 | 46 | (0.64–2.092) | ||||
| TRAF1.C5 | No | 33 | 26 | 1.082 | 0.87 | 22 | 37 | 0.934 | 0.87 | 17 | 42 | 1.424 | 0.35 |
| Yes | 61 | 52 | (0.574–2.038) | 44 | 69 | (0.487–1.784) | 25 | 88 | (0.695–2.919) | ||||
| PAD4 | No | 26 | 22 | 1.807 | 0.2 | 28 | 20 | 1.108 | 0.83 | 38 | 10 | 1.005 | 1 |
| Yes | 17 | 26 | (0.784–4.163) | 24 | 19 | (0.482–2.545) | 34 | 9 | (0.365–2.768) | ||||
| OR for developing anti-VCP antibodies in the presence of HLA-DRB1 shared epitope alleles | |||||||||||||
| HLA-DRB*0101 | No | 66 | 63 | 0.561 | 0.15 | 45 | 84 | 0.561 | 0.1 | 31 | 98 | 0.92 | 0.83 |
| Yes | 28 | 15 | (0.273–2.975) | 21 | 22 | (0.279–1.129) | 11 | 32 | (0.415–2.038) | ||||
| HLA-DRB*0401 | No | 57 | 38 | 1.621 | 0.126 | 54 | 50 | 2.4 | 0.007 | 30 | 65 | 2.5 | 0.02 |
| Yes | 37 | 40 | (0.883–2.975) | 21 | 56 | (1.261–4.566) | 12 | 65 | (1.177–5.306) | ||||
| HLA-DRB*0404 | No | 88 | 65 | 2.93 | 0.05 | 63 | 90 | 3.733 | 0.04 | 40 | 113 | 3.008 | 0.16 |
| Yes | 6 | 13 | (1.058–8.127) | 3 | 16 | (1.043–13.35) | 2 | 17 | (0.665–13.60) | ||||
| HLA-DRB*0405 | No | 88 | 72 | 1.222 | 0.77 | 62 | 98 | 1.265 | 0.76 | 41 | 119 | 3.789 | 0.29 |
| Yes | 6 | 6 | (0.377–3.952) | 4 | 8 | (0.365–4.379) | 1 | 11 | (0.474–30.266) | ||||
| HLA-DRB*0408 | No | 90 | 74 | 1.216 | 1 | 63 | 101 | 1.039 | 1 | 40 | 124 | 0.967 | 1 |
| Yes | 4 | 4 | (0.294–5.029) | 3 | 5 | (0.240–4.501) | 2 | 6 | (0.187–4.986) | ||||
| HLA-DRB*0102 | No | 72 | 66 | 0.595 | 0.24 | 52 | 86 | 0.863 | 0.7 | 30 | 108 | 0.509 | 0.12 |
| Yes | 22 | 12 | (0.273–1.396) | 14 | 20 | (0.402–1.856) | 12 | 22 | (0.226–1.146) | ||||
| HLA-DRB*1002 | No | 66 | 63 | 0.561 | 0.15 | 45 | 84 | 0.561 | 0.1 | 31 | 98 | 0.92 | 0.83 |
| Yes | 28 | 15 | (0.274–1.148) | 21 | 22 | (0.279–1.129) | 11 | 32 | (0.415–2.038) | ||||