Distribution of autoantibodies against different histone proteins found in sera from 100 patients with systemic lupus erythematosus (SLE). Antibody reactivity in the sera was determined by ELISA and immunoblot analysis.
| Anti-histone Antibody Specificity | Patients with SLE, n = 100 |
|---|---|
| H1, H3 | 12 |
| H1 | 11 |
| H3 | 5 |
| H1, H2A, H3 | 5 |
| H2B, H3 | 4 |
| H1, H2B, H3 | 3 |
| H1, H2B, H3, H4 | 3 |
| H1, H3, H4 | 2 |
| H4 | 1 |
| H2A | 1 |
| H2A, H4 | 1 |
| H2B, H3, H4 | 1 |
| H2A, H2B, H3 | 1 |
| H2A, H2B, H3, H4 | 1 |
| H1, H2A, H2B, H3, H4 | 1 |
| Negative | 48 |