Sensitivity, specificity, and positive and negative predictive values of various rules for identifying patients with a SLICC renal activity score of 4 points or more based on VCAM-1 and NGAL.
| Definition of a “Positive” Test | Sensitivity, % | Specificity, % | Positive Predictive Value, % | Negative Predictive Value, % |
|---|---|---|---|---|
| VCAM-1/creatinine ratio | ||||
| > 0.1 | 79 | 73 | 66 | 84 |
| > 0.2 | 54 | 88 | 75 | 74 |
| > 0.3 | 34 | 93 | 75 | 68 |
| NGAL/creatinine ratio | ||||
| > 0.1 | 45 | 57 | 43 | 61 |
| > 0.2 | 28 | 75 | 45 | 61 |
| > 0.3 | 20 | 86 | 54 | 62 |
VCAM-1: vascular cell adhesion molecule-1; NGAL: neutrophil gelatinase-associated lipocalin; SLICC: Systemic Lupus International Collaborating Clinics.