Reported cases of Candida krusei arthritis.
| Case 16 | Case 27 | Case 38 | Case 49 | Case 510 | Present Case | |
|---|---|---|---|---|---|---|
| Year published | 1982 | 1987 | 2006 | 2007 | 2007 | 2011 |
| Age, yrs | 18 | 41 | 62 | 79 | 57 | 75 |
| Sex | M | M | M | M | M | M |
| Underlying disease | Drug addiction | AML | AML | AML | Lymphoma* | AML |
| Neutropenic | No | Yes | Yes | Yes | Yes | Yes |
| Fever | No | Yes | Yes | Yes | No | Yes |
| Arthritis | Left knee | Right knee | Spondylodiscitis | Right knee | Right knee | Right knee |
| Synovial fluid | Turbid | Serous | NA | Serous | Turbid | Serous |
| Macroscopic quantity, cc | NA | 10 | NA | NA | NA | 60 |
| WBC | 4.4 × 109/l | 2.8 × 109/l | NA | 1.9 × 109/l | 30 × 109/l | 5–10/hpf |
| Positive sample culture | Synovial liquid | Sputum and synovial liquid | CT-guided fine-needle biopsy | Synovial liquid | Synovial liquid and urine | Synovial liquid |
| C krusei treatment | Clotrimazole | Amphotericin B | Amphotericin B + caspofungin + voriconazole | NA | Amphotericin B followed by voriconazole | Posaconazole followed by caspofungin |
| Infection outcome | Cured | Cured | Cured | Death | Cured | Death†† |
| Devices | No | CVC | CVC | No | NA | CVC |
| Previous antibiotic | No | No | Yes | Yes | Yes | Yes |
| Antifungal prophylaxis | No | No | Fluconazole | Fluconazole† | Fluconazole | Voriconazole |
AML: acute myelogenous leukemia; WBC: white blood cell count; NA: not available; CVC: central venous catheter.
↵* Diffuse B cell lymphoma.
↵† Patient was receiving treatment with fluconazole because of C. tropicalis arthritis. C. krusei was isolated in subsequent arthrocentesis.
↵†† Bacterial infection.