Table 2.

Association of initial symptoms/signs, and clinical, laboratory, and radiographic features with juvenile versus adult-onset ankylosing spondylitis. The OR corresponds to a unit-increase in the variable if not addressed.

FeatureOR (95% CI)†
Initial symptoms/signs
  Back pain0.48 (0.26–0.87)*
  Peripheral arthritis2.23 (1.29–3.86)*
  Enthesitis1.41 (0.65–3.05)
  Uveitis1.16 (0.49–2.70)
  Peripheral arthritis/enthesitis only2.35 (1.24–4.45)*
OutcomeOR (95% CI)††
  BASDAI1.01 (0.89–1.14)
  BASFI1.13 (1.02–1.25)*
  BASMI0.93 (0.79–1.10)
  BASG1.17 (1.06–1.30)*
  CRP > 0.5 vs ≤ 0.5 mg/dl2.04 (0.75–5.55)
  ESR > 20 vs ≤ 20 mm/h1.55 (0.77–3.12)
  IgA > 453 vs ≤ 453 mg/dl2.63 (1.38–4.99)*
  Sacroiliitis1.26 (0.91–1.75)
  BASRI-hip1.19 (0.96–1.48)
  mSASSS cervical spine0.97 (0.94–1.00)
  mSASSS lumbar spine0.95 (0.92–0.99)*

  • ↵† Adjusted for sex and HLA-B27.

  • ↵†† Adjusted for sex, HLA-B27, and disease duration.

  • ↵* Statistical significance. Definitions as in Table 1.