CDAI with Interaction | ||||
---|---|---|---|---|
N | Estimated Coefficient | SE | p | |
Subjects | 1205 | |||
Observations used | 5691 | |||
Intercept | 136.23 | 63.789 | 0.0329 | |
Baseline disease activity prior to smoking cessation (reference: continued smoker) | −0.345 | 0.104 | 0.0009 | |
Change in square-root CDAI over time (months) | −2.761 | 2.591 | 0.2866 | |
Effect of smoking on change in square-root CDAI over time (months) (reference: continued smoker) | −0.00091 | 0.00330 | 0.7834 | |
Use of biologic (reference: none) | 0.569 | 0.0849 | < 0.0001 | |
Time*biologic | −0.00137 | 0.00379 | 0.7185 | |
Use of MTX only (reference: none) | 0.255 | 0.0928 | 0.0064 | |
Time*MTX | −0.0040 | 0.00434 | 0.3560 | |
Time*index year | 0.00137 | 0.00129 | 0.2893 | |
DMARD only (reference: none) | 0.471 | 0.134 | 0.0008 | |
Time*DMARD | −0.00563 | 0.00627 | 0.3693 | |
Prednisone (reference: none) | −0.237 | 0.0660 | 0.0004 | |
Time*Prednisone | −0.0014 | 0.00288 | 0.6263 | |
Age | −0.00539 | 0.00348 | 0.1214 | |
Sex (reference: female) | 0.0223 | 0.0881 | 0.8006 | |
Race (reference: white) | ||||
African American | 0.247 | 0.174 | 0.1557 | |
Asian | 0.0144 | 0.362 | 0.9683 | |
Hispanic | 0.193 | 0.173 | 0.2635 | |
Other | −0.0594 | 0.275 | 0.8288 | |
Duration of followup, yrs | −0.0473 | 0.0277 | 0.0880 | |
Disease duration, yrs | 0.0207 | 0.00446 | < 0.0001 | |
Biologic starts (reference: none)† | NA | NA | NA | |
Biologic stops (reference: none)† | NA | NA | NA | |
DMARD-only starts (reference: none) | −0.175 | 0.121 | 0.1509 | |
DMARD-only stops (reference: none) | −0.134 | 0.126 | 0.2903 | |
MTX starts (reference: none) | −0.354 | 0.143 | 0.0147 | |
MTX stops (reference: none) | −0.188 | 0.136 | 0.1702 | |
Time*DMARD-only starts | 0.00333 | 0.00559 | 0.5512 | |
Time*DMARD-only stops | 0.0126 | 0.00605 | 0.0371 | |
Time*MTX starts | 0.00318 | 0.00705 | 0.6515 | |
Time*MTX stops | −0.00243 | 0.00647 | 0.7071 |
↵† There is no change of the status of using biologic during the followup period. The statistics associated with the variables are denoted not applicable (NA).