Patient measures.
| Patient | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Characteristic | 3 | 6 | 10 | 4 | 5 | 7 | 8 | 9 | 11 | 2 | 12 | 13 | 1 |
| Response at Week 14 | R | R | R | R | R | R | R | R | R | NR | NR | NR | NR |
| ACR response at Week 14 | 70 | 70 | 70 | 50 | 50 | 50 | 50 | 50 | 50 | 20 | 20 | 20 | 0 |
| Gender | F | F | F | F | F | F | M | F | F | M | M | M | F |
| Duration of disease, mo | 36 | 480 | 204 | 24 | 192 | 24 | 60 | 156 | 96 | 48 | 156 | 180 | 300 |
| Smoking (Brinkman index) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 150 | 375 | 240 | 0 |
| DAS28 at Week | |||||||||||||
| 0 | 5.36 | 5.06 | 5.2 | 4.36 | 5.07 | 5.21 | 5.15 | 6 | 5.82 | 7 | 4.62 | 5.21 | 6.42 |
| 4 | 3.33 | 3.62 | 2.39 | 2.53 | 6 | 3.75 | 3.86 | 4.88 | 2.8 | 6.21 | 3.1 | 1.21 | 3.98 |
| 14 | 0.16 | 1.21 | 1.64 | 2.54 | 2.68 | 3.2 | 3.82 | 3.21 | 1.97 | 4 | 2.72 | 3.37 | 5.82 |
| HAQ at Week | |||||||||||||
| 0 | 1.375 | 2.25 | 0.75 | 1.375 | 2.62 | 2.125 | 1 | 2.75 | 2.25 | 1.75 | 1.75 | 1.875 | 0.75 |
| 4 | 1.625 | 1.125 | 0.5 | 0.5 | 2.125 | 2 | 1 | 2.625 | 1.875 | 2.25 | 1.875 | 1.25 | 1.5 |
| 14 | 0.25 | 0.125 | 0.375 | 0.625 | 1.5 | 1.75 | 0.5 | 1.25 | 2 | 1.875 | 1.625 | 1.25 | 1.5 |
| CRP at Week | |||||||||||||
| 0 | 8.02 | 23.2 | 12.4 | 4.7 | 12 | 0.4 | 40.25 | 15.6 | 7.77 | 45.4 | 178.18 | 2.34 | 12.5 |
| 4 | 0.5 | 2.51 | 0.52 | 1.5 | 4 | 0.6 | 22.81 | 8.7 | 0.5 | 45.4 | 161.81 | 0.5 | 3.87 |
| 14 | 0.5 | 0.54 | 0.9 | 0.5 | 0.5 | 0.5 | 16.7 | 5.4 | 0.5 | 129.56 | 59.6 | 0.5 | 3.2 |
| ESR at Week | |||||||||||||
| 0 | 8 | 22 | 22 | 14 | 40 | 10 | 50 | 40 | 50 | 23 | 90 | 10 | 38 |
| 4 | 2 | 8 | 2 | 5 | 11 | 6 | 19 | 28 | 2 | 33 | 76 | 2 | 6 |
| 14 | 1 | 4 | 4 | 7 | 9 | 3 | 18 | 4 | 2 | 80 | 20 | 8 | 28 |
| Previous DMARD | 2 | 3 | 3 | 5 | 4 | 2 | 3 | 3 | 5 | 4 | 6 | 2 | 3 |
| MTX dose, mg/wk | 15 | 15 | 7.5 | 20 | 10 | 15 | 12.5 | 20 | 15 | 7.5 | 15 | 20 | 10 |
| Prednisone use, mg/wk | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 8 | 4 | 0 | 4 | 0 |
| Comorbidity | None | HT | None | None | None | HT | None | HT | CD | None | None | None | HT |
Data are shown as mean ± SD regarding the total group; and mean ± range in both responders and nonresponders. ACR: American College of Rheumatology criteria; R: responder, NR: nonresponder, Brinkman index: no. cigarettes smoked per day × smoking years, calculated by summing separate Brinkman indices in 3 age periods; DAS28: Disease Activity Score; HAQ: Health Assessment Questionnaire; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; DMARD: disease-modifying antirheumatic drug; MTX: methotrexate, HT: hypertension, CD: Crohn disease.