Frequency of deep-vein thrombosis and pulmonary embolism in patients with rheumatoid arthritis stratified by GDF15 SNP genotypes. All analyses adjusted for sex, shared-epitope, accumulated disease activity, ACPA, hypertension, diabetes mellitus, ever-smoker, treatment with statins and anti-TNF inhibitor, and age at onset.
| Genes/SNP | Negative | Positive, n (%)* | OR (95% CI), Unadjusted | OR (95% CI), Adjusted |
|---|---|---|---|---|
| GDF15 rs1058587 | ||||
| CC | 311 | 9 (2.8) | 1.0 (referent) | |
| CG | 279 | 14 (4.8) | 1.73 (0.74–4.07) | 1.02 (0.38–2.72) |
| GG | 61 | 6 (9.0) | 3.40 (1.17–9.90) | 3.32 (1.08–10.20) |
| GG vs CG+CC | 61 | 6 (9.0) | 2.52 (0.99–6.44) | 3.29 (1.19–9.10) |
| Allele G | 401 | 26 (6.1) | 1.83 (1.07–3.10) | 3.29 (1.19–9.09) |
↵* Percentage of all patients with a given type. ACPA: anticitrullinated protein antibodies; SNP: single-nucleotide polymorphism; TNF: tumor necrosis factor.