Table 1.

Summary of cases of AA amyloidosis in patients with giant cell arteritis and/or polymyalgia rheumatica.

Patient, Age (yrs), Sex	GCA or PMR, GCA Biopsy?	Amyloidosis Manifestation, Organ Involvement	Therapy for GCA/PMR, Duration of Treatment	Therapy for Amyloidosis, Duration of Treatment	Outcome/Followup
1, 79 F^*	GCA/PMR, TA biopsy neg, MRI pos	Nephrotic syndrome, renal	Prednisone 5–60 mg/day, 1.5 yrs	Colchicine 0.3 mg/day, 4 mo	Stabilization of kidney function
2, 59 M²	GCA/PMR, TA biopsy pos	Renal, GI, cardiac, lung, thyroid, adrenal, GU, spleen	Pred 75 mg/day initially, then tapered, 2 yrs	Pred 75 mg/day initially, then tapered, 2 yrs	Death due to cardiac complications, ESRD
3, 76 F³	GCA/PMR, TA biopsy pos	Nephrotic syndrome, renal, GI, cardiac, GU, spleen, adrenal	Pred 5–60 mg/day, 5 yrs	Pred 5–60 mg/day, 5 yrs	Death due to ESRD
4, 73 M⁴	GCA/PMR, TA biopsy pos	Diagnosed at autopsy only: spleen, GI, GU, renal cardiac	Pred 10–40 mg/day, MTX 15 mg/week, 11 yrs	None (diagnosed at autopsy)	Death from complication from VP shunt for NPH
5, 74 F⁵	GCA/PMR, TA biopsy pos	Nephrotic syndrome, renal	Pred 25 mg/day initially, then refusal to take steroids, unknown duration	Deflazacort 60 mg/day, chlorambucil 5 mg/day, unknown duration	Unknown
6, 81 F⁶	GCA/PMR, TA biopsy pos	Nephrotic syndrome, renal	Pred 60 mg/day, then tapered, colchicine 2 mg/day, 18 months	Pred 60 mg/day, then tapered, colchicine 2 mg/day, 18 mo	Improvement in proteinuria
7, 71 F⁶	GCA/PMR, TA biopsy neg	Nephrotic syndrome, renal	Pred 5–60 mg/day, 2.5 yrs	Pred 60 mg/day, then tapered, colchicine 2 mg/day, 6 mo	Stabilization of proteinuria and creatinine
8, 72 M⁷	GCA/PMR	Nephrotic syndrome, renal	Not specified, 16 mo	Pulse pred 300 mg/day × 3, then 70 mg/day, colchicine not tolerated, chlorambucil, 3 yrs	ESRD
9, 65 M⁸	GCA, TA biopsy, fibrosis	Nephrotic syndrome, renal, rectal	Initially pred 60 mg/day, 1 yr	Initially pred 60 mg/day, 1 yr	Death due to ESRD
10, 82 M³	PMR, TA biopsy neg	Nephrotic syndrome, renal	Pred 5–20 mg/day, 4 yrs	Continued pred with no dose change, 2 mo	Death due to ESRD
11, 66 F⁹	PMR	Nephrotic syndrome, renal	Pred 20 mg then tapered over 6 mo, pred and MTX for flare after discharge, 1 yr	Low-dose pred to keep inflammatory markers near normal	Stabilization of creatinine

↵* Our case. GCA: giant cell arteritis; PMR: polymyalgia rheumatica; TA: temporal artery; GI: gastrointestinal; GU: genitourinary; pred: prednisone; ESRD: endstage renal disease; VP: ventriculoperitoneal; NPH: normal pressure hydrocephalus; MTX: methotrexate.