Multivariate analysis demonstrating associations of lipid measures and inflammatory markers with the ApoE genotypes. Bold text indicates statistically significant result (p < 0.05).
| E2 (E2E2, E2E3) | E4 (E3E4, E4E4) | |||
|---|---|---|---|---|
| Beta (95% CI) | p | Beta (95% CI) | p | |
| Total Cholesterol | ||||
| Crude | −0.77 (−1.13 to −0.41) | < 0.001 | 0.03 (−0.27 to 0.33) | 0.853 |
| Model a | −0.76 (−1.12 to −0.42) | < 0.001 | 0.06 (−0.22 to 0.35) | 0.661 |
| Model b | −0.76 (−1.13 to 0.39) | < 0.001 | 0.02 (−0.29 to 0.32) | 0.912 |
| Model c | −0.69 (−1.07 to −0.33) | < 0.001 | 0.05 (−0.25 to 0.35) | 0.737 |
| LDL | ||||
| Crude | −0.76 (−1.13 to −0.39) | < 0.001 | 0.36 (0.05 to 0.67) | 0.022 |
| Model a | −0.73 (−1.43 to −0.40) | < 0.001 | 0.37 (0.06 to 0.68) | 0.018 |
| Model b | −0.78 (−1.18 to −0.38) | < 0.001 | 0.39 (0.06 to 0.72) | 0.020 |
| Model c | −0.73 (−1.13 to −0.34) | < 0.001 | 0.42 (0.10 to 0.74) | 0.009 |
| ApoB | ||||
| Crude | −0.15 (−0.25 to −0.06) | 0.001 | 0.10 (0.02 to 0.18) | 0.011 |
| Model a | −0.16 (−0.26 to −0.07) | 0.001 | 0.11 (0.03 to 0.19) | 0.006 |
| Model b | −0.18 (−0.28 to −0.08) | 0.001 | 0.10 (0.02 to 0.18) | 0.020 |
| Model c | −0.17 (−0.26 to 0.07) | 0.001 | 0.11 (0.03 to 0.19) | 0.009 |
| CRP (log) | ||||
| Crude | 0.11 (−0.02 to 0.24) | 0.101 | −0.18 (−0.29 to −0.07) | 0.002 |
| Model a | 0.10 (−0.03 to 0.23) | 0.143 | −0.17 (−0.29 to −0.06) | 0.002 |
| Model b | 0.09 (−0.05 to 0.23) | 0.194 | −0.16 (−0.27 to −0.04) | 0.007 |
| Model c | 0.11 (−0.03 to 0.25) | 0.138 | −0.15 (−0.27 to −0.04) | 0.007 |
| ESR (log) | ||||
| Crude | 0.011 (−0.13 to 0.15) | 0.873 | −0.21 (−0.33 to −0.09) | 0.001 |
| Model a | 0.01 (−0.13 to 0.14) | 0.928 | −0.19 (−0.31 to −0.08) | 0.001 |
| Model b | −0.02 (−0.16 to 0.12) | 0.774 | −0.19 (−0.30 to −0.08) | 0.001 |
| Model c | −0.01 (−0.14 to 0.14) | 0.966 | −0.18 (−0.29 to −0.72) | 0.001 |
| DAS | ||||
| Crude | −0.03 (−0.44 to 0.51) | 0.890 | −0.55 (−0.96 to 0.14) | 0.008 |
| Model a | −0.01 (−0.48 to 0.46) | 0.971 | −0.49 (−0.89 to −0.08) | 0.019 |
| Model b | −0.11 (−0.55 to 0.33) | 0.620 | −0.45 (−0.82 to −0.07) | 0.019 |
| Model c | −0.01 (−0.45 to 0.43) | 0.957 | −0.46 (−0.83 to −0.09) | 0.015 |
Crude: uncorrected data. Model a: Crude data plus adjustment for age and sex. Model b: Model a plus adjustment for demographics (BMI/smoking status) and markers of disease activity/severity (rheumatoid factor positivity ± CRP: adjusted for only in lipid models not ESR, CRP, or DAS. Model c: Model b plus adjustment for medications (methotrexate, sulfasalazine, hydroxychloroquine, prednisolone, anti-tumor necrosis factor therapy); BMI: body mass index; LDL: low-density lipoprotein; ApoB: apolipoprotein B; ESR: erythrocyte sedimentation rate; DAS: Disease Activity Score; CRP: C-reactive protein.