Recently identified biomarkers for psoriatic disease.
| Biomarker | Screening* | Disease Activity | Treatment Response | Radiographic Change† |
|---|---|---|---|---|
| Peripheral blood/serum/plasma | ||||
| Bone alkaline phosphatase | ✓ | |||
| C-reactive protein | ✓ | ✓ | ✓ | ✓ |
| Cartilage oligomeric matrix protein | ✓ | ✓ | ||
| Ratio of C-propeptide of type II collagen to collagen fragment neoepitopes Col2–3/4 (long mono) | ✓ | |||
| Interleukin 6 (IL-6) | ✓ | ✓ | ||
| Matrix metalloproteinase-3 | ✓ | ✓ | ✓ | |
| Melanoma inhibitory activity | ✓ | |||
| Macrophage-colony stimulating factor | ✓ | |||
| Osteoprotegerin | ✓ | |||
| Circulating osteoclast precursors | ✓ | |||
| Receptor activator of nuclear factor kappa-B ligand | ✓ | |||
| Synovial fluid | ||||
| Chemokine (C-C motif) ligand 3 | ✓ | ✓ | ||
| IL-1 | ✓ | ✓ | ||
| IL-1 receptor antagonist | ✓ | ✓ | ||
| IL-6 | ✓ | ✓ | ||
| IL-8 | ✓ | ✓ | ||
| Synovial tissue | ||||
| CD3-positive cells | ✓ | |||
| Skin | ||||
| IL-17 pathway genes | ✓ |