Characteristics of patients with idiopathic pulmonary arterial hypertension (IPAH).
| Characteristics | Unmatched, n = 155 | Matched, n = 66 | Absolute Standardized Difference | |||
|---|---|---|---|---|---|---|
| No Warfarin, n = 64 | Warfarin, n = 91 | No Warfarin, n = 33 | Warfarin, n = 33 | Unmatched n = 155 | Matched n = 66 | |
| Female sex, n (%) | 42 (66) | 66 (73) | 20 (61) | 21 (64) | 0.12 | 0.05 |
| PAH characteristics at diagnosis | ||||||
| mPAP mm Hg, mean (SD) | 52.9 (13.5) | 42.6 (13.3) | 51.6 (15.6) | 47.5 (15.9) | 0.77 | 0.26 |
| WHO Functional Class III/IV | 29 (45) | 54 (59) | 18 (55) | 18 (55) | 0.20 | 0 |
| Moderate-severe RV enlargement | 1 (2) | 16 (18) | 1 (3) | 4 (12) | 0.17 | 0.09 |
| Moderate-severe RV hypokinesis | 19 (30) | 50 (55) | 13 (39) | 17 (52) | 0.33 | 0.16 |
| Comorbidities, n (%) | ||||||
| Cancer | 3 (5) | 10 (11) | 3 (9) | 1 (3) | 0.07 | 0.06 |
| Coronary artery disease | 8 (13) | 16 (18) | 4 (12) | 1 (3) | 0.06 | 0.09 |
| Diabetes mellitus | 14 (22) | 15 (16) | 9 (27) | 7 (21) | 0.07 | 0.02 |
| Hyperlipidemia | 8 (13) | 7 (8) | 3 (9) | 1 (3) | 0.05 | 0.06 |
| Hypertension | 24 (38) | 24 (26) | 10 (30) | 11 (33) | 0.13 | 0.04 |
| Peripheral vascular disease | 1 (2) | 1 (1) | 0 | 0 | 0.01 | 0 |
| Ischemic stroke | 2 (3) | 8 (9) | 1 (3) | 2 (6) | 0.06 | 0.03 |
| Concomitant medications | ||||||
| Calcium channel blocker | 12 (19) | 33 (36) | 11 (33) | 12 (36) | 0.21 | 0.04 |
| ER antagonist | 11 (17) | 43 (47) | 9 (27) | 8 (24) | 0.37 | 0.04 |
| PDE inhibitor | 12 (19) | 24 (26) | 9 (27) | 8 (24) | 0.09 | 0.04 |
| Prostaglandin analog | 3 (5) | 24 (26) | 1 (3) | 4 (12) | 0.24 | 0.09 |
mPAP: mean pulmonary artery pressure; RV: right ventricular; WHO: World Health Organization; RV: right ventricular; ER: endothelin receptor; PDE: phosphodiesterase.