Genotyping and allele frequency of IL-12B A1188C and IL-23R C2370A polymorphisms in patients with AS and in healthy controls.
| Genotype | AS, n = 362 (%) | Control, n = 362 (%) | p | RRm (95% CI) | |
|---|---|---|---|---|---|
| IL-12B | CC | 73 (20.2) | 62 (17.1) | 0.0044 | 1.93 (1.23–3.03) |
| AC | 189 (52.2) | 155 (42.8) | 0.0025 | 1.73 (1.21–2.46) | |
| AA | 100 (27.6) | 145 (40.1) | — | 1.00 (reference) | |
| C | 335 (46.3) | 279 (38.5) | 0.0011 | 1.45 (1.16–1.81) | |
| A | 389 (53.7) | 445 (61.5) | — | 1.00 (reference) | |
| IL-23R | AA | 204 (56.4) | 193 (53.3) | 0.9569 | 1.02 (0.58–1.80) |
| CA | 125 (34.5) | 137 (37.9) | 0.2693 | 0.86 (0.49–1.54) | |
| CC | 33 (9.1) | 32 (8.8) | — | 1.00 (reference) | |
| A | 533 (73.6) | 523 (72.2) | 0.5373 | 1.08 (0.84–1.39) | |
| C | 191 (26.4) | 201 (27.8) | 1.00 (reference) |
RRm: matched relative risk; AS: ankylosing spondylitis.