Characteristics of subjects in the secondary prevention of cardiovascular disease.
| Osteoarthritis | Rheumatoid Arthritis | |||||
|---|---|---|---|---|---|---|
| Characteristic | Statin-exposed | Statin-unexposed | p | Statin-exposed | Statin-unexposed | p |
| No. subjects | 175 | 72 | 60 | 18 | ||
| Age, yrs | 70.8 (9.6) | 75.7 (9.6) | < 0.01 | 68.1 (9.9) | 70.2 (9.4) | 0.34 |
| Male, n (%) | 95 (54.6) | 36 (50.0) | 0.51 | 29 (48.3) | 11 (61.1) | 0.34 |
| Baseline total cholesterol concentration, mmol/l | 4.54 (1.07) | 4.72 (1.05) | 0.22 | 4.95 (1.28) | 5.00 (1.15) | 0.88 |
| Social economic status | ||||||
| 1 (most deprived) | 50 (28.6) | 18 (25.0) | 0.32 | 18 (30.0) | 5 (27.8) | 0.18 |
| 2 | 30 (17.1) | 21 (29.2) | 12 (20.0) | 8 (44.4) | ||
| 3 | 29 (16.6) | 9 (12.5) | 9 (15.0) | 1 (5.6) | ||
| 4 | 31 (17.7) | 11 (15.3) | 14 (23.3) | 4 (22.2) | ||
| 5 (most affluent) | 31 (17.7) | 11 (15.3) | 7 (11.7) | 0 | ||
| Concurrent use of drugs | ||||||
| Analgesics | 156 (89.1) | 58 (80.6) | 0.07 | 55 (91.7) | 14 (77.8) | 0.11 |
| Positive inotropic drugs | 6 (3.4) | 12 (16.7) | < 0.01 | 7 (11.7) | 2 (11.1) | 0.95 |
| Diuretics | 100 (57.1) | 46 (63.9) | 0.33 | 39 (65.0) | 8 (44.4) | 0.12 |
| Beta-adrenoceptor-blocking drugs | 94 (53.7) | 22 (30.6) | < 0.01 | 41 (68.3) | 6 (33.3) | < 0.05 |
| Hypertension and heart failure drugs | 124 (70.9) | 40 (55.6) | < 0.05 | 48 (80.0) | 8 (44.4) | < 0.05 |
| Nitrates and calcium-channel blockers | 130 (74.3) | 54 (75.0) | 0.91 | 51 (85.0) | 13 (72.2) | 0.22 |
| Anticoagulants | 13 (7.4) | 13 (18.1) | < 0.05 | 13 (21.7) | 3 (16.7) | 0.65 |
| Antiplatelets | 152 (86.9) | 49 (68.1) | < 0.01 | 45 (75.0) | 14 (77.8) | 0.81 |
| Corticosteroids | 46 (26.3) | 21 (29.2) | 0.64 | 32 (53.3) | 14 (77.8) | 0.06 |
| Nonsteroidal antiinflammatory drugs | 71 (40.6) | 30 (41.7) | 0.65 | 34 (56.7) | 9 (50.0) | 0.62 |
| Drugs that suppress RA process | — | — | — | 43 (71.7) | 13 (72.2) | 0.70 |
| Comorbidity | ||||||
| Diabetes mellitus | 14 (8.0) | 6 (8.3) | 0.93 | 11 (18.3) | 3 (16.7) | 0.87 |
| Angina, TIA, heart failure | 17 (9.7) | 10 (13.9) | 0.34 | 9 (15.0) | 5 (27.8) | 0.22 |
TIA: transient ischemic attack.