Table 2.

Predictors of a moderate or good European League Against Rheumatism (EULAR) response in early and established rheumatoid arthritis (RA); generalized estimating equations (GEE) model.

Outcome Variable: Moderate/Good EULAR Response	RA ≤ 2 Years		RA > 2 Years
Outcome Variable: Moderate/Good EULAR Response	Coefficient (95% CI)	p	Coefficient (95% CI)	p
Sex^*	0.93 (0.31, 1.55)	0.003	0.02 (−0.32, 0.36)	0.90
Followup, months	0.08 (0.05, 0.12)	< 0.0005	0.02 (0.009, 0.04)	0.001
Sex × followup	−0.08 (−0.12, − 0.04)	< 0.0005	0.003 (−0.01, 0.02)	0.70
Age^**	−0.01 (−0.02, 0.003)	0.14	−0.002 (−0.01, 0.006)	0.62
RA duration^**	0.18 (−0.14, 0.49)	0.27	−0.002 (−0.01, 0.008)	0.70
DAS28^**	0.46 (0.25, 0.67)	< 0.0005	0.62 (0.52, 0.72)	< 0.0005
Anti-TNF therapy^**	0.05 (−0.22, 0.32)	0.72	0.18 (0.05, 0.30)	0.006
Methotrexate^**	0.76 (0.33, 1.19)	0.001	0.25 (0.05, 0.46)	0.01
Prednisolone^**	−0.32 (−0.72, 0.08)	0.11	−0.31 (−0.50, −0.12)	0.002
Intercept	−2.28 (−3.83, −0.72)	0.004	−2.36 (−3.15, —1.57)	< 0.0005

Covariates adjusted for in the model are listed as independent variables.
↵* The referent group for sex was male.
↵** For these covariates, only baseline values were adjusted for in the GEE model. DAS28: 28-joint Disease Activity Score and C-reactive protein; TNF: tumor necrosis factor.