Table 4.

Multivariable associations of rheumatoid arthritis (RA) patient characteristics with higher quartiles of soluble CD14 (sCD14).

Variable	Clinical Model	Clinical Model plus rs2915863 (CD14/–1720)	Clinical Model plus rs2569193 (CD14/–2838)	Clinical Model plus rs2569190 (CD14/–260)	Clinical Model plus rs2915863 (CD14/–1720)
Age at enrollment, yrs	1.02 (1.00 to 1.03)^†	1.02 (1.00 to 1.03)^†	1.02 (1.01 to 1.03)^†	1.02 (1.00 to 1.03)^†	1.02 (1.00 to 1.03)^†
Race
White	1.00 (Referent)	1.00 (Referent)	1.00 (Referent)	1.00 (Referent)	1.00 (Referent)
African American	0.52 (0.38 to 0.71)^††	0.49 (0.35 to 0.67)^††	0.51 (0.37 to 0.70)^††	0.53 (0.38 to 0.72)^††	0.54 (0.39 to 0.75)^††
Other non-white	0.95 (0.60 to 1.52)	0.95 (0.59 to 1.52)	1.10 (0.69 to 1.75)	0.96 (0.60 to 1.53)	0.98 (0.60 to 1.58)
Body mass index	0.98 (0.96 to 1.00)^*	0.98 (0.96 to 1.00)	0.98 (0.96 to 1.00)^*	0.98 (0.96 to 1.00)	0.98 (0.96 to 1.00)
hsCRP ≥ 3 mg/ml	2.09 (1.59 to 2.74)^††	2.02 (1.54 to 2.66)^††	2.12 (1.61 to 2.80)^††	2.06 (1.57 to 2.71)^††	2.07 (1.58 to 2.72)^††
DAS28 category
<2.6 (remission)	1.00 (Referent)	1.00 (Referent)	1.00 (Referent)	1.00 (Referent)	1.00 (Referent)
2.6 to 3.2 (low activity)	1.39 (0.92 to 2.11)	1.38 (0.91 to 2.11)	1.35 (0.88 to 2.06)	1.40 (0.92 to 2.13)	1.40 (0.92 to 2.12)
3.3 to 5.1 (moderate activity)	1.50 (1.08 to 2.10)^*	1.55 (1.10 to 2.17)^*	1.46 (1.04 to 2.05)^*	1.54 (1.10 to 2.16)^*	1.55 (1.11 to 2.17)^*
> 5.1 (high activity)	1.78 (1.22 to 2.59)^†	1.84 (1.25 to 2.70)^†	1.77 (1.21 to 2.59)^†	1.84 (1.26 to 2.69)^†	1.87 (1.28 to 2.75)^†
rs5744455 (CD14/–651)
TT	—	1.00 (Referent)	—	—	—
CT or CC		0.77 (0.60 to 0.99)^*
rs2569193 (CD14/–2838)
GG	—	—	1.00 (Referent)	—	—
AG or AA			1.27 (1.00 to 1.61)
rs2569190 (CD14/–260)
GG	—	—	—	1.00 (Referent)	—
AG or AA				1.04 (0.80 to 1.35)
rs2915863 (CD14/–1720)
TT	—	—	—	—	1.00 (Referent)
CT or CC					1.11 (0.86 to 1.43)

↵* p < 0.05,
↵† p < 0.01,
↵†† p < 0.001; results from multivariable ordinal regression; all other values nonsignificant. hsCRP: high sensitivity C-reactive protein; DAS: Disease Activity Score.