Median change (interquartile range) in red blood cell MTXGlun concentration between Week 0 and Week 24 in responders (∅DAS28 > 0.6) and nonresponders (∅DAS28 ≤ 0.6).
| Concentration | Nonresponders, n = 16 | Responders, n = 10 | p |
|---|---|---|---|
| MTXGlu1 | −0.1 (−6.6–5.8) | 2.2 (−4.4–13.0) | 0.32 |
| MTXGlu2 | −2.3 (−5.3–7.8) | 0.0 (−2.1–4.5) | 0.43 |
| MTXGlu3 | 12.0 (6.5–19.6) | 18.1 (6.3–29.4) | 0.23 |
| MTXGlu4 | 8.15 (1.5–20.0) | 18.3 (6.6–25.7) | 0.058 |
| MTXGlu5 | 2.0 (0.0–9.7) | 7.15 (3.9–21.5) | 0.023 |
| MTXGlu3–5 | 20.75 (14.1–43.7) | 50.1 (23.6–70.9) | 0.023 |
| MTXGlu1–5 | 26.65 (6.3–62.15) | 53.2 (21.9–89.6) | 0.045 |
MTXGlun: methotrexate polyglutamate; DAS28: 28-joint Disease Activity Score.