Overview of therapies that showed a correlation between infiltration of CD68-positive macrophages in RA synovial tissue and disease activity and response to treatment.
| Treatment |
| Leflunomide23 |
| Methotrexate23 |
| Infliximab24 |
| CCR1-antagonist25 |
| Prednisolone17 |
| Anti-CCL2 antibody26 |
| C5aR-antagonist27 |
| Rituximab28 |
| Anti-CCR2 antibody29 |
| CCR5 antagonist30 |
CCR: CC chemokine receptor; CCL: CC chemokine ligand.