Baseline characteristics of patients in the CZP 200 mg + MTX responder subgroups.
| Change in DAS28 ≥ 1.2 | ACR20 | |||||
|---|---|---|---|---|---|---|
| Characteristics | Week 6 Responders, (n = 195) | Week 12 Responders, (n = 45) | All Responders, (n = 240) | Week 6 Responders, (n = 172) | Week 12 Responders, (n = 72) | All Responders, (n = 244) |
| Age, yrs, mean (SD) | 50.6 (12.3) | 55.0 (8.9) | 51.4 (11.8) | 50.8 (12.2) | 52.3 (10.6) | 51.2 (11.7) |
| Female, % | 80.0 | 91.1 | 82.1 | 83.1 | 76.4 | 81.1 |
| No. previous DMARD, mean (SD) | 1.3 (1.3) | 1.3 (1.2) | 1.3 (1.3) | 1.3 (1.3) | 1.1 (1.1) | 1.2 (1.2) |
| Disease duration, yrs, mean (SD) | 5.45 (4.00) | 7.29 (4.38) | 5.79 (4.13) | 5.76 (4.13) | 5.85 (3.89) | 5.79 (4.05) |
| MTX dose ≥ 15 mg/week, % | 50.8 | 37.8 | 48.3 | 50.6 | 34.7 | 45.9 |
| Steroid use, % | 60.0 | 66.7 | 61.3 | 59.9 | 58.3 | 59.4 |
| RF-positive, ≥ 14 IU/ml, % | 81.0 | 82.2 | 81.3 | 82.6 | 81.9 | 82.4 |
| SJC, mean (SD) | 22.59 (9.59) | 21.40 (10.92) | 22.37 (9.84) | 22.74 (9.47) | 20.78 (10.36) | 22.16 (9.76) |
| TJC, mean (SD) | 30.82 (11.85) | 30.00 (12.39) | 30.66 (11.93) | 31.06 (12.00) | 28.00 (12.18) | 30.16 (12.11) |
| mTSS, mean (SD) | 34.88 (42.97) | 46.14 (46.98) | 36.99 (43.87) | 34.74 (42.41) | 39.81 (45.69) | 36.24 (43.37) |
| DAS28, range 0–10, mean (SD) | 6.97 (0.78) | 6.83 (0.81) | 6.95 (0.79) | 6.89 (0.81) | 6.98 (0.83) | 6.92 (0.81) |
| Pain VAS, range 0–100 mm, mean (SD) | 62.0 (19.5) | 63.1 (18.8) | 62.2 (19.3) | 62.1 (19.3) | 63.9 (19.6) | 62.6 (19.3) |
| HAQ-DI, range 0–3, mean (SD) | 1.64 (0.64) | 1.82 (0.61) | 1.67 (0.64) | 1.64 (0.64) | 1.72 (0.61) | 1.67 (0.63) |
| FAS, range 0–10, mean (SD) | 6.4 (2.0) | 6.6 (1.9) | 6.4 (2.0) | 6.3 (1.9) | 6.8 (2.2) | 6.4 (2.0) |
| CRP, mean mg/l (SD) | 27.34 (26.42) | 21.40 (23.45) | 26.23 (25.95) | 25.22 (23.12) | 29.28 (35.27) | 26.41 (27.26) |
DAS28: Disease Activity Score 28; ACR20: American College of Rheumatology 20% response; DMARD: disease-modifying antirheumatic drug; MTX: methotrexate; RF: rheumatoid factor; SJC: swollen joint count; TJC: tender joint count; mTSS: mean Total Sharp Score; VAS: visual analog scale; HAQ-DI: Health Assessment Questionnaire-Disability Index; FAS: Fatigue Assessment Scale; CRP: C-reactive protein.