Conditional logistic regression of log-marker levels with active disease vs remission (n = 151). Results expressed as OR for active disease per unit-increase in log-marker level.
| Marker | Crude Association | Adjusted for CRP | Adjusted for PR3-ANCA | Adjusted for All Markers | ||||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | Std ß | OR (95% CI) | Std ß | OR (95% CI) | Std ß | OR (95% CI) | Std ß | |
| sCD40L | 4.72 (2.47, 9.03) | 0.75 | 4.26 (2.22, 8.17) | 0.70 | 3.08 (1.60, 5.96) | 0.54 | 3.66 (1.38, 9.72) | 0.62 |
| CRP | 1.54 (1.16, 2.04) | 0.33 | — | 1.47 (1.04, 2.08) | 0.30 | 1.06 (0.59, 1.90) | 0.05 | |
| IL-6 | 1.04 (0.63, 1.71) | 0.01 | 0.79 (0.45, 1.40) | –0.07 | 0.64 (0.34, 1.19) | –0.14 | 0.92 (0.23, 3.65) | –0.02 |
| IL-8 | 1.93 (1.33, 2.80) | 0.33 | 1.68 (1.15, 2.47) | 0.26 | 1.89 (1.22, 2.92) | 0.32 | 3.19 (1.23, 8.28) | 0.59 |
| MCP-1 | 0.36 (0.22, 0.57) | –0.46 | 0.23 (0.13, 0.42) | –0.58 | 0.45 (0.27, 0.76) | –0.35 | 0.13 (0.04, 0.51) | –0.78 |
| P-selectin | 6.26 (2.78, 14.10) | 0.82 | 5.26 (2.27, 12.19) | 0.70 | 3.57 (1.52, 8.41) | 0.57 | 2.54 (0.82, 7.84) | 0.40 |
| VEGF | 2.13 (1.38, 3.29) | 0.44 | 1.77 (1.13, 2.77) | 0.33 | 2.05 (1.21, 3.46) | 0.41 | 1.28 (0.46, 3.61) | 0.14 |
| PR3-ANCA | 9.41 (4.03, 21.99) | 1.01 | 11.86 (4.40, 31.95) | 1.10 | — | 5.56 (1.49, 20.74) | 0.75 | |
Std ß: standardized ß estimate; sCD40L: soluble CD40 ligand; CRP: C-reactive protein; IL: interleukin; MCP-1: monocyte chemoattractant protein 1; VEGF: vascular endothelial growth factor; PR3-ANCA: antiproteinase 3 antineutrophil cytoplasmic antibody.