Vδ1+ and Vγ9+ T cells in synovial fluid in different JIA subtypes, as percentage of total T cells. Data are mean ± SD of percentage Vδ1+ and Vγ9+ subsets among CD3+ T cells in freshly isolated synovial fluids of 93 patients with JIA subtypes or (for Vγ9+ T cells only) in 10-day synovial fluid mononuclear cell cultures triggered with 100 IU/ml recombinant human IL-2 alone (IPP0) or with 2 μg/ml isopentenyl pyrophosphate (IPP2).
| Subtype | N (% of total) | Vδ1+ | Vγ9 | IPP0 (n) | IPP2 (n) |
|---|---|---|---|---|---|
| All cohorts | 93 (100) | 5.06 ± 4.30 | 5.39 ± 3.78 | 5.13 ± 3.15 (70) | 29.1 ± 24.4 (70) |
| Persistent | 47 (50.5) | 5.68 ± 4.69 | 6.45 ± 4.28 | 5.59 ± 3.10 (32) | 33.4 ± 26.7 (32) |
| Extended | 10 (10.8) | 5.86 ± 3.29 | 3.57 ± 1.97 | 4.93 ± 2.84 (8) | 30.6 ± 21.5 (8) |
| Polyarthritis | 12 (12.9) | 4.70 ± 3.50 | 5.57 ± 2.48 | 6.99 ± 3.89* (9) | 20.0 ± 20.6 (9) |
| Psoriatic | 5 (5.4) | 5.35 ± 6.75 | 6.20 ± 3.76 | 6.14 ± 2.52 (5) | 45.6 ± 22.0 (5) |
| Systemic | 11 (11.8) | 3.34 ± 3.93 | 3.02 ± 3.13 | 2.44 ± 1.98* (10) | 18.7 ± 22.1 (10) |
| Enthesitis-related arthritis | 3 (3.2) | 1.50 ± 0.89 | 4.57 ± 2.74 | 4.85 ± 0.64 (2) | 41 ± 13.7 (2) |
| Other | 5 (5.4) | 3.47 ± 3.22 | 2.90 ± 2.79 | 3.35 ± 2.62 (4) | 12.6 ± 15.7 (4) |
↵* p < 0.05 (ANOVA) between subgroups of patients for the respective measurement. N: number of patients studied.