Age, yrs | 59 (54–64) |
Body mass index, kg/m2 | 27.6 (25.5–29.7) |
Estimated creatinine clearance, ml/min* | 76.5 (65.5–87.6) |
Plasma urate concentration at baseline taking allopurinol, mmol/l | 0.37 (0.34–0.41) |
History of gout, n (%) | |
Duration of gout < 10 yrs | 12 (60) |
Presence of ≥ tophi | 5 (30) |
No. acute attacks in past 2 yrs | |
0 | 4 (20) |
1–3 | 6 (30) |
4–5 | 3 (15) |
> 5 | 7 (35) |
Duration of allopurinol therapy < 5 yrs | 12 (60) |
Concomitant medications at study entry, n (%) | |
No regular medicines | 3 (17) |
Aspirin 100 mg/day | 3 (17) |
Diuretics** | 4 (22) |
Warfarin | 2 (11) |
Angiotensin II receptor antagonists (no losartan) | 3 (17) |
ß-adrenergic receptor antagonists | 3 (17) |
Angiotensin converting enzyme inhibitors | 4 (22) |
Calcium channel blockers | 2 (11) |
HMG-CoA reductase inhibitors | 7 (39) |