Genotype, allele, and allelic combination frequencies of the rs3790567 IL12RB and rs1343151 IL23R gene polymorphisms in patients with biopsy-proven GCA and healthy controls.
| GCA | Controls | p | OR (95% CI) | |
|---|---|---|---|---|
| rs3790567 IL12RB | n = 352 (%) | n = 574 (%) | ||
| GG | 166 (47.2) | 319 (55.6) | 1, Reference | |
| GA | 160 (45.4) | 215 (37.5) | 0.011 | 1.43 (1.07–1.91) |
| AA | 26 (7.4) | 40 (6.9) | 0.41 | 1.25 ((0.71–2.18) |
| GA+AA | 186 (52.8) | 255 (44.4) | 0.013 | 1.40 (1.06–1.85) |
| 2n = 704 | 2n = 1148 | |||
| G | 492 (69.9) | 853 (74.3) | 1, Reference | |
| A | 212 (30.1) | 295 (25.7) | 0.039 | 1.25 (1.01–1.54) |
| rs1343151 IL23R | n = 348 (%) | n = 574 (%) | ||
| GG | 144 (41.4) | 236 (41.1) | 1, Reference | |
| GA | 159 (45.7) | 260 (45.3) | 0.99 | 1.00 (0.75–1.35) |
| AA | 45 (12.9) | 78 (13.6) | 0.79 | 0.95 (0.61–1.47) |
| 2n = 696 | 2n = 1148 | |||
| G | 447 (64.2) | 732 (63.8) | 1, Reference | |
| A | 249 (35.8) | 416 (36.2) | 0.84 | 0.98 (0.80–1.20) |
| IL12RB-IL23R | 2n = 532 | 2n = 916 | ||
| G-G | 280 (52.6) | 502 (54.8) | 1, Reference | |
| A-G | 122 (22.9) | 235 (25.7) | 0.59 | 0.93 (0.71–1.22) |
| G-A | 81 (15.2) | 114 (12.4) | 0.14 | 1.27 (0.91–1.78) |
| A-A | 49 (9.2) | 65 (7.1) | 0.14 | 1.35 (0.89–2.05) |
| D′ | 0.21 | |||
| r2 | 0.033 |