Association of polymorphisms in the IRF5 gene with susceptibility to macrophage activation syndrome (MAS) in patients with systemic juvenile idiopathic arthritis (JIA).
| SNP, Subject Subset | No. (%) with Genotype | Allelic Association | ||||||
|---|---|---|---|---|---|---|---|---|
| Total | OR | (95% CI) | p | pc | ||||
| rs729302 | AA | AC | CC | |||||
| MAS | 22 (66.7) | 10 (30.3) | 1 (3.0) | 33 | 2.45 | 1.11–5.42 | 0.03 | 0.08 |
| Non-MAS | 20 (41.7) | 23 (47.9) | 5 (10.4) | 48 | 1.0 | — | — | — |
| rs2004640 | GG | GT | TT | |||||
| MAS | 9 (27.3) | 15 (45.5) | 9 (27.3) | 33 | 0.24 | 0.11–0.54 | 0.001 | 0.003 |
| Non-MAS | 27 (56.3) | 21 (43.8) | 0 (0.0) | 48 | 1.0 | — | — | — |
| rs2280714 | CC | CT | TT | |||||
| MAS | 14 (42.4) | 17 (51.5) | 2 (6.1) | 33 | 2.12 | 1.08–4.40 | 0.045 | 0.13 |
| Non-MAS | 14 (29.2) | 27 (56.3) | 7 (14.6) | 48 | 1.0 | — | — | — |
pc: corrected combined p value using the Bonferroni method. IRF5: interferon regulatory factor 5; SNP: single-nucleotide polymorphism.