Table 2.

Comparison of percentage of respondents who selected each feature by continent.

Feature	Europe, N = 92	North America, N = 90	Other Continents, N = 50	p	Comparisons Significant on post-hoc Test^*
Falling platelet count	81.5	92.2	86	0.1
Hyperferritinemia	88	91.1	62	0.0002	EU vs OC
Hyperferritinemia	88	91.1	62	0.0002	NA vs OC
Increased liver enzymes	69.6	86.7	64	0.004	EU vs NA
Increased liver enzymes	69.6	86.7	64	0.004	NA vs OC
Falling white blood cell count	70.7	82.2	66	0.07
Bone marrow hemophagocytosis	79.3	81.1	84	0.8
Persistent continuous fever ≥ 38° C	73.9	56.7	78	0.01	EU vs NA
Persistent continuous fever ≥ 38° C	73.9	56.7	78	0.01	NA vs OC
Falling erythrocyte sedimentation rate	50	67.8	70	0.02	EU vs NA
Hypofibrinogenemia	63	64.4	52	0.3
Hypertriglyceridemia	69.6	50	52	0.02	EU vs NA
Central nervous system dysfunction	53.3	32.2	52	0.009	EU vs NA
Central nervous system dysfunction	53.3	32.2	52	0.009	NA vs OC
Falling hemoglobin level	34.8	47.8	50	0.1
Prolongation of clotting times	20.7	44.4	44	0.001	EU vs NA
Prolongation of clotting times	20.7	44.4	44	0.001	EU vs OC
Increased D-dimer	18.5	48.9	30	0.0006	EU vs NA
Hemorrhagic manifestations	33.7	22.2	42	0.04	NA vs OC
Liver enlargement	41.3	15.6	38	0.0004	EU vs NA
Liver enlargement	41.3	15.6	38	0.0004	NA vs OC
Spleen enlargement	27.2	16.7	34	0.06
Increased lactic dehydrogenase	26.1	17.8	10	0.06
Increased soluble IL-2 receptor α	10.9	30	4	< 0.0001	EU vs NA
Increased soluble IL-2 receptor α	10.9	30	4	< 0.0001	NA vs OC
Increased soluble CD163	3.3	21.1	10	0.0008	EU vs NA
Generalized lymphadenopathy	14.1	3.3	12	0.03	EU vs NA
Decreased albumin	8.7	6.7	10	0.8
Hyponatremia	15.2	2.2	0	< 0.0001	EU vs NA
Hyponatremia	15.2	2.2	0	< 0.0001	EU vs OC
Arthritis improvement	9.8	2.2	6	0.1
Renal failure	4.3	5.6	8	0.7
Increased bilirubin	4.3	2.2	6	0.5
Jaundice	4.3	1.1	8	0.1
Respiratory failure	3.3	2.2	2	0.9
Cardiac failure	3.3	0	4	0.2

↵* Pairs of comparisons that were statistically significant after Bonferroni correction for multiple comparisons. EU: Europe; NA: North America; OC: other continents.