Table 3.

Amino acid combinations for variants in Gln³²⁶ codon in unrelated individuals.

	SNP Combination			Corresponding Amino Acid	Function	Unrelated Carriers^*
	1st base: rs12077871	2nd base: rs7533552	3rd base: monomorphic	Corresponding Amino Acid	Function	Controls, n (%)	Hip OA, n (%)
	C	A	G	Gln	WT	96 (67.1)	36 (49.3)
	C	A	G	Gln	WT	96 (67.1)	36 (49.3)
	C	A	G	Gln	WT	41 (28.7)	28 (38.4)
	C	G	G	Arg	P	41 (28.7)	28 (38.4)
	C	A	G	Gln	WT	3 (2.1)	1 (1.4)
	T	G	G	Trp	P	3 (2.1)	1 (1.4)
	C	G	G	Arg	P	3 (2.1)	7 (9.6)
	C	G	G	Arg	P	3 (2.1)	7 (9.6)
	C	G	G	Arg	P	0 (0.0)	1 (1.4)
	T	G	G	Trp	P	0 (0.0)	1 (1.4)
Total						143 (100)	73 (100)

↵* Unrelated individuals used in chi-square test: one twin of each monozygotic twin pair was randomly selected for genotyping. From dizygotic pairs, affected individual from discordant pairs and random individual from concordant pairs were selected. SNP: single-nucleotide polymorphism; OA: osteoarthritis; WT: wild-type allele; P: predisposing allele; Gln: glutamine; Arg: arginine; Trp: tryptophan.