Gene | rs Number | MAF | Disc Degeneration | p values (hip OA)* | Gene | rs Number | MAF | Disc Degeneration | p values (hip OA)* | ||
---|---|---|---|---|---|---|---|---|---|---|---|
Dominant | Recessive | Dominant | Recessive | ||||||||
AGC1 | rs939587 | 0.280 | X | 0.888 | 0.920 | COL11A1 | rs1415359 | 0.400 | 0.374 | 0.332 | |
rs4932424 | 0.280 | X | 0.480 | 0.488 | rs1337185 | 0.180 | X | 0.439 | 0.362 | ||
rs3825996 | 0.490 | X | 1.000 | 1.000 | rs1463035 | 0.180 | X | 0.258 | 0.230 | ||
rs1042631 | 0.230 | X | 0.498 | 1.000 | rs3753841 | 0.320 | 0.597 | 0.498 | |||
rs1516797 | 0.340 | X | 0.115 | 0.082 | COL11A2 | rs2072915 | 0.240 | X | 0.124 | 0.106 | |
COL1A1 | rs1800012 | 0.120 | 0.171 | 0.168 | rs9277933 | 0.240 | X | 0.308 | 0.277 | ||
rs2075555 | 0.130 | X | 0.202 | 0.229 | rs2076311 | 0.240 | X | 0.237 | 0.207 | ||
rs1007086 | 0.270 | X | 0.888 | 0.888 | rs2855432 | 0.300 | 0.399 | 0.299 | |||
rs909102 | 0.140 | 0.037 | 0.032 | rs2257126 | 0.360 | 0.862 | 0.806 | ||||
COL1A2 | rs3763468 | 0.050 | 0.078 | 0.091 | rs734181 | 0.180 | 0.191 | 0.142 | |||
rs388625 | 0.400 | 0.920 | 0.920 | ILA | rs2071375 | 0.350 | X | 0.916 | 0.923 | ||
rs412777 | 0.420 | 0.045 | 0.048 | ILB | rs1143634 | 0.260 | 0.071 | 0.068 | |||
rs400218 | 0.350 | 0.383 | 0.351 | IL1R1 | rs1465325 | 0.200 | 0.512 | 0.617 | |||
rs1034620 | 0.200 | 0.777 | 0.841 | rs956730 | 0.280 | 1.000 | 0.920 | ||||
OL2A1 | rs1859443 | 0.180 | 0.365 | 0.390 | rs3917225 | 0.410 | 0.517 | 0.502 | |||
rs1635529 | 0.200 | 0.303 | 0.299 | rs2287047 | 0.250 | 0.538 | 0.532 | ||||
rs2276453 | 0.390 | 0.920 | 0.920 | rs3771200 | 0.430 | 0.036 | 0.033 | ||||
rs917055 | 0.200 | 0.354 | 0.330 | IL1R2 | rs740044 | 0.160 | 0.718 | 0.791 | |||
rs2276458 | 0.360 | 0.431 | 0.396 | rs4141134 | 0.260 | 0.450 | 0.450 | ||||
rs6823 | 0.470 | 0.371 | 0.340 | rs719250 | 0.190 | 0.284 | 0.299 | ||||
COL3A1 | rs1878199 | 0.290 | 0.823 | 1.000 | rs3218984 | 0.410 | 0.269 | 0.245 | |||
rs2056156 | 0.470 | 0.663 | 0.603 | rs1008394 | 0.410 | 0.269 | 0.265 | ||||
rs2203601 | 0.470 | 0.450 | 0.446 | IL1RL1 | rs1420089 | 0.130 | 0.054 | 0.040 | |||
rs1800255 | 0.230 | 0.383 | 0.488 | rs1997466 | 0.490 | 1.000 | 1.000 | ||||
COL5A1 | rs4842138 | 0.120 | 0.233 | 0.271 | rs1041973 | 0.240 | 0.142 | 0.142 | |||
rs4341231 | 0.490 | 0.180 | 0.221 | rs12905 | 0.270 | 0.242 | 0.194 | ||||
rs3128619 | 0.480 | 0.498 | 0.498 | IL1RL2 | rs2241132 | 0.130 | 0.157 | 0.080 | |||
rs10858281 | 0.450 | 0.273 | 0.368 | rs870684 | 0.400 | 0.095 | 0.062 | ||||
rs7357740 | 0.490 | 0.127 | 0.177 | rs1922290 | 0.400 | 0.067 | 0.049 | ||||
COL5A2 | rs1983318 | 0.110 | 0.578 | 0.560 | rs1922295 | 0.400 | 0.069 | 0.051 | |||
rs13005821 | 0.340 | 0.920 | 0.920 | rs1997502 | 0.350 | 0.232 | 0.216 | ||||
rs2138374 | 0.310 | 0.740 | 1.000 | rs2302612 | 0.140 | 0.572 | 0.590 | ||||
rs12693527 | 0.200 | 0.888 | 0.888 | rs1558626 | 0.460 | 0.888 | 0.888 | ||||
rs1131518 | 0.663 | 0.680 | IL18R1 | rs2287037 | 0.390 | 0.752 | 0.920 | ||||
COL9A1 | rs696990 | 0.160 | X | 0.322 | 0.406 | rs2270298 | 0.270 | 0.202 | 0.148 | ||
rs564031 | 0.400 | 0.192 | 0.192 | rs1035130 | 0.270 | 0.320 | 0.294 | ||||
rs592121 | 0.320 | 0.327 | 0.359 | rs1420096 | 0.480 | 0.084 | 0.053 | ||||
rs2076816 | 0.400 | 0.213 | 0.187 | IL18RAP | rs1420106 | 0.210 | X | 0.240 | 0.245 | ||
rs1200564 | 0.070 | 1.000 | 1.000 | rs1420100 | 0.480 | X | 0.110 | 0.068 | |||
rs997953 | 0.380 | 1.000 | 1.000 | rs917997 | 0.200 | X | 0.191 | 0.244 | |||
COL9A2 | rs449541 | 0.340 | 0.158 | 0.196 | MMP3 | rs645419 | 0.390 | 0.192 | 0.238 | ||
rs364281 | 0.370 | 0.920 | 0.888 | rs646910 | 0.250 | 0.322 | 0.380 | ||||
rs7533552 | 0.175 | X | 0.0033 | 0.0025 | MMP8 | rs1940475 | 0.470 | 0.791 | 1.000 | ||
COL9A3 | rs3891033 | 0.450 | 0.127 | 0.134 | rs2509013 | 0.380 | 1.000 | 1.000 | |||
rs1046789 | 0.270 | 1.000 | 1.000 | rs1276283 | 0.330 | 0.777 | 0.764 | ||||
COL10A1 | rs549332 | 0.470 | 0.178 | 0.125 | MMP9 | rs3918241 | 0.170 | 0.152 | 0.081 | ||
rs1064583 | 0.340 | 0.030 | 0.025 | rs2664538 | 0.380 | 0.271 | 0.322 | ||||
rs3812111 | 0.340 | 0.024 | 0.011 | rs20544 | 0.490 | 0.087 | 0.091 | ||||
rs568725 | 0.320 | 0.002 | 0.004 | MMP13 | rs2252070 | 0.400 | 0.028 | 0.063 | |||
rs3819089 | 0.110 | 0.192 | 0.227 |
↵* Noncorrected (significance threshold = 0.00073). Disc degeneration: X denotes SNP associated with any of the disc degeneration phenotypes in our previous study4 (p < 0.05 after 1000 permutations). Dominant, Recessive: Dominant and recessive mode of inheritances in the association analysis using the Pseudomarker program. MAF: minor allele frequency in Finnish population; SNP: single-nucleotide polymorphism; OA: osteoarthritis.