Characteristic | Completers, n = 117 | Lost to Study, n = 15 | p |
---|---|---|---|
Age, yrs | 63.7 (10.3) | 58.4 (11.4) | 0.07 |
No. female (%)* | 68 (58) | 5 (33.3) | 0.07 |
BMI, kg/m2 | 28.9 (5.1) | 28.3 (4.6) | 0.68 |
Kellgren-Lawrence, n ≥ grade 2* (%) | 84 (72) | 7 (47) | 0.09 |
WOMAC | |||
Pain | 80.9 (43.9) | 102.7 (18.6) | 0.01 |
Stiffness | 39.6 (22.2) | 49.2 (19.2) | 0.21 |
Function | 306.6 (169.8) | 399.4 (54.3) | 0.12 |
Total | 427.1 (225.5) | 551.3 (171.6) | 0.11 |
Tibial cartilage volume, ml | |||
Medial | 1.74 (0.5) | 1.82 (0.5) | 0.53 |
Lateral | 1.92 (0.6) | 2.20 (0.6) | 0.08 |
Tibial plateau bone area, cm2 | |||
Medial | 20.8 (3.9) | 21.5 (4.2) | 0.49 |
Lateral | 13.6 (2.6) | 14.0 (1.9) | 0.58 |
Markers of bone formation** | |||
PINP, μg/la | 40.6 (11.2–177.4) | 38.7 (26.0–49.4) | 0.67 |
Osteocalcin, ng/mlb | 16.8 (6.2–48.9) | 18.7 (6.2–39.4) | 0.83 |
Markers of bone resorption** | |||
CTX-I, ng/mlc | 0.29 (0.03–1.12) | 0.27 (0.02–1.41) | 0.57 |
ICTP, ng/mlb | 3.5 (2.01–11.68) | 3.5 (2.2–3.9) | 0.45 |
NTX-I, nM BCEd | 19.8 (7.8–78.13) | 21.3 (12.5–28.4) | 0.30 |
↵** Values are median (range). Mann-Whitney U test for comparison of medians due to skewed distribution of raw data.
↵* Chi-square tests for comparison of proportions. Biomarker data available at baseline for 122 subjectsa, 124 subjectsb, 123 subjectsc, 120 subjectsd. Of 15 subjects lost to followup, 9 had biomarker data at baseline. PINP: intact N-terminal propeptide of type I procollagen; NTX-I: N-telopeptide of type I collagen; CTX-I: C-telopeptide of type I collagen; ICTP: C-telopeptide of type I collagen; BMI: body mass index; WOMAC: Western Ontario and McMaster Universities Osteoarthritis index.