Demographic data for patient population. Eighty of the 81 patients with renal disease had evidence of active renal disease during the study interval. P value was obtained from GEE model, adjusting for repeated measures (using autoregressive correlation structure) for multiple pregnancies in the same mother. Hypertension was defined as systolic > 140 mm Hg, diastolic > 90 mm Hg, or taking antihypertensive medications.
| Characteristic | All Pregnancies, N = 193 | Nonrenal, N = 112 | Renal, N = 81 | p |
|---|---|---|---|---|
| Age at diagnosis, yrs | 22.2 ± 5.0 | 22.7 ± 5.4 | 21.5 ± 4.4 | 0.01 |
| Age at pregnancy, yrs | 29.8 ± 4.7 | 30.8 ± 4.5 | 28.3 ± 4.7 | 0.002 |
| Disease duration at pregnancy, yrs | 7.6 ± 5.4 | 8.1 ± 5.6 | 6.9 ± 5.1 | 0.27 |
| SLEDAI-2K at presentation | 8.8 ± 5.9 | 7.3 ± 5.2 | 10.9 ± 6.2 | 0.08 |
| SLEDAI-2K pre-pregnancy | 4.2 ± 3.8 | 3.5 ± 3.5 | 5.2 ± 4.0 | 0.008 |
| AMS during study period | 4.6 ± 3.4 | 3.2 ± 2.2 | 6.5 ± 3.9 | < 0.0001 |
| SLEDAI-2K (excluding renal) pre-pregnancy | 3.3 ± 3.2 | 3.5 ± 3.5 | 3.0 ± 2.8 | 0.23 |
| AMS (excluding renal) during study period | 3.5 ± 2.6 | 3.2 ± 2.2 | 3.9 ± 2.9 | 0.20 |
| Hypertension, n (%) | 35 (18.1) | 13 (11.6) | 22 (27.2) | 0.18 |
| Diabetes, n (%) | 7 (3.7) | 6 (5.4) | 1 (1.3) | 0.17 |
| Antiphospholipid antibody, n (%) | 92 (51.7) | 57 (54.8) | 35 (47.3) | 0.59 |
GEE: generalized estimating equations; SLEDAI-2K: Systemic Lupus Erythematosus Disease Activity Index 2000; AMS: adjusted mean SLEDAI-2K.