Any Plaque§ | Log bulb-ICA–IMT# | Log CCA-IMT# | |||||||
---|---|---|---|---|---|---|---|---|---|
Characteristic* | ß-RA | ß-MESA | p*** | ß-RA | ß-MESA | p*** | ß-RA | ß-MESA | p*** |
Male vs female† | 1.16 | 1.34 | 0.83 | 0.17** | 0.11** | 0.41 | 0.11** | 0.11** | 0.94 |
Age, per year†† | 1.06** | 1.10** | 0.41 | 0.012** | 0.013** | 0.89 | 0.005** | 0.009** | 0.034 |
Hypertension† | 1.46 | 3.36** | 0.20 | 0.024 | 0.127** | 0.17 | 0.028 | 0.067** | 0.20 |
Ever vs never smoking† | 1.76 | 1.19 | 0.57 | 0.13 | −0.07 | 0.071 | 0.037 | −0.039 | 0.10 |
Log IL-6, per unit†† | 0.75 | 3.77** | 0.002 | −0.032 | 0.11* | 0.002 | 0.004 | 0.032** | 0.13 |
↵* All models included the characteristic listed in addition to covariates for age, gender, race, highest educational attainment, systolic and diastolic blood pressure, antihypertensive use, HDL and LDL cholesterol, smoking, triglycerides, log IL-6, and use of lipid-lowering medication.
↵** p < 0.05 for association of characteristic with the carotid outcome within groups defined by RA status (RA or MESA control).
↵*** p < 0.05 indicates significant heterogeneity between RA and control participants in the adjusted association of the characteristic with the carotid outcome.
↵† ß-coefficients represent difference in carotid outcome between participants with the characteristic vs those without the characteristic.
↵†† ß-coefficients represent change in carotid outcome associated with a one-unit increase in the characteristic.
↵§ Estimates obtained using multivariable logistic regression, ß-coefficients are adjusted odds ratios.
↵# Estimates obtained using multivariate linear regression: ß-coefficients are adjusted means.