Risk of death due to cardiovascular disease (n = 26) among 190 patients with RA. Multivariate Cox proportional-hazards regression analysis based on forward stepwise selection and adjusted for sex and age at inclusion. Predictor variables included in the analysis were HAQ score, CRP > 100 mg/dl, state of nutrition below normal, presence of diabetes, MBL2 genotype YA/YA, and serum MBL. Patients with incomplete information on risk factors (n = 39) were not included in the analysis.
| HR (95% CI) | p | |
|---|---|---|
| HAQ score | 2.1 (1.2–3.7) | 0.015 |
| CRP > 100 mg/dl | 2.7 (1.1–6.7) | 0.031 |
| Nutrition below normal | 3.6 (1.4–8.9) | 0.007 |
| MBL2 genotype YA/YA | 2.7 (1.2–5.9) | 0.016 |
HR: hazard ratio; HAQ: Health Assessment Questionnaire; CRP: C-reactive protein; MBL: mannose-binding lectin.