Minimal important difference (MID) estimates for single-site SSc patients.
| Patient-rated Overall Status | HAQ-DI Change, mean (SD) [95% CI] | HAQ-DI Change, 75th percentile† | Pain VAS†† Change, mean (SD) [95% CI] | Fatigue VAS Change, mean (SD) [95% CI] | Sleep VAS Change, mean (SD) [95% CI] | Global VAS Change, mean (SD) [95% CI] |
|---|---|---|---|---|---|---|
| Better (n = 10) | –0.0125 (0.224) [–0.173 to 0.148] | 0.125 | –8.00 (32.48) [–31.23 to 15.23] | –10.00 (10.63) [–17.60 to 2.40] | –18.50 (33.91) [–42.76 to 5.76] | –6.70 (26.58) [–25.72 to 12.32] |
| Same (n = 57) | –0.009 (0.255) [–0.077 to 0.058] | 0.125 (0.255) | –0.49 (17.25) [–5.07 to 4.09] | 3.25 (21.60) [–2.48 to 8.98] | –3.05 (22.40) [–9.00 to 2.89] | –5.70 (19.48) [–10.87 to –0.53] |
| Worse (n = 38) | 0.042 (0.314) [–0.061 to 0.145] | 0.217 | 3.61 (24.52) [–4.46 to 11.67] | 3.79 (25.32) [–4.53 to 12.11] | 5.92 (28.83) [–3.55 to 15.40] | 4.05 (22.35) [–3.29 to 11.40] |
| Much worse* (n = 3) | 0.327 (0.263) [–0.327 to 0.981] | n is too small | 0.67 (34.01) [–83.81 to 85.14] | 45.33 (27.93) [–24.06 to 114.73] | 3.00 (11.27) [–24.99 to 30.99] | 36.33 (15.18) [–1.37 to 74.03] |
| Spearman Correlation | 0.106 | 0.092 | 0.211 | 0.256 | 0.276 | |
| Coefficient** | p < 0.05 | p < 0.01 | p < 0.01 |
↵* There was only 1 patient much better (not shown) and 3 patients much worse.
↵** Correlation is between anchor and mean change in score, significant at the level shown.
↵† 75th percentile of HAQ-DI change score was taken for each subgroup except much worse because it contained only 3 patients.
↵†† VAS 0 to 100 mm. HAQ-DI: Health Assessment Questionnaire-Disability Index; VAS: visual analog scale.