Laboratory and immunological abnormalities of patients with primary SS according to parotid scintigraphic involvement. Data are no. (%).
| Characteristics | Class 4, n = 44 | Class 2–3, n = 314 | Class 1, n = 47 | p* |
|---|---|---|---|---|
| ESR > 50 mm/h | 12 (27) | 71/304 (23) | 3/45 (7) | 0.027 |
| Anemia (Hb < 10 g/dl) | 10 (23) | 30/308 (10) | 1/46 (2) | 0.005 |
| Leukopenia (< 4/mm3) | 13 (29) | 46/308 (15) | 4/46 (9) | 0.017 |
| Thrombocytopenia (< 100) | 4 (9) | 19/309 (6) | 0/46 (0) | 0.150 |
| Hypergammaglobulin > 25% | 3/38 (8) | 27/283 (9) | 0/40 (0) | 0.123 |
| ANA | 41 (93) | 257/311 (83) | 41/46 (89) | 0.128 |
| ANA > 320 | 18/33 (54) | 73/229 (32) | 7/30 (23) | 0.016 |
| RF | 28 (64) | 121/309 (39) | 13/45 (29) | 0.002 |
| Anti-Ro/SSA | 25 (57) | 99/313 (32) | 10/46 (22) | 0.001 |
| Anti-La/SSB | 22/44 (50) | 72/313 (23) | 5/46 (11) | < 0.001 |
| Cryoglobulins | 4/39 (10) | 16/268 (6) | 2/40 (5) | 0.552 |
| Low C3 | 8/43 (19) | 32/299 (11) | 8/45 (18) | 0.173 |
| Low C4 | 9/43 (21) | 19/299 (6) | 1/45 (2) | 0.001 |
| Low CH50 | 12/43 (28) | 28/296 (9) | 2/44 (4) | 0.001 |
↵* Pearson chi-square, 2-sided. SS: Sjögren’s syndrome; ESR: erythrocyte sedimentation rate; ANA: antinuclear antibody; RF: rheumatoid factor.