Marker | Risk Allele Frequencies* | OR (95% CI) | Single Marker p | p for Conditional Analysis | LD (r2) with Promoter Indel | |||
---|---|---|---|---|---|---|---|---|
Cases | Controls | CGGGG Indel | rs2070197 | CGGGG Indel + rs2070197 | ||||
Mexico | ||||||||
CGGGG indel | 0.559 | 0.360 | 2.25 (1.70–3.00) | 6.79 × 10−9 | — | 0.021 | — | — |
rs2004640 | 0.632 | 0.423 | 2.35 (1.75–3.15) | 8.72 × 10−9 | 0.017 | 0.146 | 0.670 | 41 |
rs2070197 | 0.427 | 0.187 | 3.24 (2.32–4.51) | 7.79 × 10−13 | 1.09 × 10−6 | — | — | 22 |
rs10954213 | 0.693 | 0.516 | 2.12 (1.57–2.86) | 7.70 × 10−7 | 0.027 | 0.132 | 0.312 | 30 |
Argentina | ||||||||
CGGGG indel | 0.469 | 0.376 | 1.47 (1.14–1.89) | 0.003 | — | 0.298 | — | — |
rs2004640 | 0.546 | 0.440 | 1.53 (1.21–1.94) | 3.56 × 10−4 | 0.132 | 0.076 | 0.463 | 67 |
rs2070197 | 0.182 | 0.094 | 2.15 (1.51–3.05) | 1.20 × 10−5 | 0.001 | — | — | 15 |
rs10954213 | 0.584 | 0.524 | 1.27 (1.01–1.61) | 0.042 | 0.769 | 0.538 | 0.541 | 50 |
Spain | ||||||||
CGGGG indel | 0.597 | 0.502 | 1.47 (1.24–1.73) | 7.15 × 10−6 | — | 0.043 | — | — |
rs2004640 | 0.636 | 0.546 | 1.45 (1.22–1.74) | 4.37 × 10−5 | 0.052 | 0.002 | 0.051 | 58 |
rs2070197 | 0.159 | 0.099 | 1.70 (1.30–2.21) | 8.30 × 10−5 | 0.029 | — | — | 10 |
rs10954213 | 0.705 | 0.662 | 1.22 (1.00–1.51) | 0.055 | 0.556 | 0.073 | 0.510 | 32 |
Italy | ||||||||
CGGGG indel | 0.532 | 0.425 | 1.54 (1.20–1.97) | 6.10 × 10−4 | — | 4.82 × 10−4 | — | — |
rs2004640 | 0.588 | 0.521 | 1.31 (1.01–1.70) | 0.042 | 1.2 × 10−5 | 0.345 | 0.003 | 34 |
rs2070197 | 0.152 | 0.071 | 2.33 (1.52–3.58) | 6.00 × 10−5 | 4.01 × 10−5 | — | — | 6 |
rs10954213 | 0.654 | 0.593 | 1.30 (1.00–1.69) | 0.053 | 1.58 × 10−4 | 0.320 | 0.007 | 26 |
Germany | ||||||||
CGGGG indel | 0.533 | 0.435 | 1.45 (1.10–1.92) | 0.004 | — | 0.248 | — | |
rs2004640 | 0.593 | 0.508 | 1.41 (1.04–1.58) | 0.007 | 0.016 | 0.080 | 3.20 × 10−4 | 17 |
rs2070197 | 0.165 | 0.090 | 1.89 (1.20–2.92) | 3.09 × 10−4 | 1.0 × 10−4 | — | — | 4 |
rs10954213 | 0.678 | 0.601 | 1.39 (0.99–1.75) | 0.011 | 1.33 × 10−3 | 0.125 | 8.02 × 10−6 | 12 |
Combined samples | ||||||||
CGGGG indel | 0.551 | 0.434 | 1.60 (1.44–1.80) | 1.58 × 10−19 | — | 5.00 × 10−7 | — | — |
rs2004640 | 0.604 | 0.497 | 1.54 (1.39–1.71) | 2.38 × 10−16 | 5.83 × 10−5 | 1.46 × 10−7 | 0.045 | 47 |
rs2070197 | 0.194 | 0.104 | 2.11 (1.81–2.45) | 2.24 × 10−23 | 3.39 × 10−15 | — | — | 9 |
rs10954213 | 0.664 | 0.592 | 1.35 (1.21–1.51) | 3.49 × 10−7 | 0.0011 | 0.030 | 0.610 | 31 |
↵* Risk alleles are insertion for promoter indel, T for rs2004640, C for rs2070197, A for rs10954213. Indel: insertion/deletion.