Table 3

Genotype by ethnic extraction.

GenotypeAshkenazi n (%)*Iraqi n (%)*North African (NAJ) n (%)*p (NAJ vs Ashkenazi or Iraqi Jewish Origin)
M694V/M694V0 (0)6 (10.3)29 (48.3)< 0.0001
V726A/V726A18 (48.6)4 (6.9)0 (0)< 0.0001
M694V/V726A1 (2.7)16 (27.6)2 (3.3)< 0.0001
M694V/E148Q1 (2.7)9 (15.5)6 (10.0)0.038***
V726A/E148Q4 (10.8)3 (5.2)0 (0)0.099
V726A/M680I1 (2.7)0 (0)0 (0)NS
M694V/?1 (2.7)13 (22.4)22 (36.7)< 0.0001^
V726A/?5 (13.5)1 (1.7)0 (0)NS
E148Q/?3 (8.1)5 (8.6)1 (1.7)NS
?/?4 (10.8)1 (1.7)0 (0)NS
Not tested**20 (35.1)4 (6.4)1 (1.6)< 0.0001
Total mutated alleles/total alleles61/74 (82.4)****95/116(81.9)97/120 (80.8)NS
  • *Percentages are computed for Ashkenazi, Iraqi, and NAJ patients with known genotype (n = 37, n = 58, and n = 60, respectively). Patients were screened for M694V, V726A, and E148Q.

  • **Percent of total.

  • ***Significant only for Iraqi vs Ashkenazi.

  • ****Two patients had 726/726/148 complex allele.

  • ^ NAJ vs Ashkenazi. NS for NAJ vs Iraqi. ? None of the studied mutations were found. NS: not significant.