Characteristics of the study population depending on the Trp64Arg polymorphism of the ADB3 gene (normouricemic persons in the baseline study who completed the followup.
| Baseline Characteristics | Characteristics at 6 Years | |||||
|---|---|---|---|---|---|---|
| Trp64Trp, n = 603 | Carriers of the Arg64 Allele, n = 88 | p* | Carriers of the Trp64Trp, n = 603 | Arg64 Allele, n = 88 | p* | |
| Age, yrs | 38.7 ± 13.0 | 39.2 ± 13.9 | NS | 44.8 ± 13.4 | 44.7 ± 13.8 | NS |
| BMI (weight/height2) | 27.1 ± 4.7 | 26.6 ± 5.6 | NS | 28.2 ± 5.1 | 27.6 ± 5.2 | NS |
| Baseline glycemia, mg/dl | 90.3 ± 9.3 | 91.6 ± 7.4 | NS | 91.1 ± 14.6 | 91.8 ± 14.2 | NS |
| Glycemia at 120 min, mg/dl | 113.6 ± 26.3 | 118.3 ± 30.0 | NS | 116.4 ± 36.8 | 120.4 ± 35.4 | NS |
| HOMA-IR | 2.27 ± 1.5 | 2.4 ± 1.5 | NS | 2.2 ± 2.0 | 1.8 ± 1.1 | NS |
| Total cholesterol, mg/dl | 196.0 ± 41.2 | 197.1 ± 43.6 | NS | 202.0 ± 39.5 | 203.6 ± 40.3 | NS |
| Triglycerides, mg/dl | 98.6 ± 72.4 | 89.4 ± 45.9 | NS | 96.9 + 68.1 | 89.2 ± 42.6 | NS |
| Uric acid, mg/dl | 4.3 ± 1.1 | 4.4 ± 1.1 | NS | 4.4 ± 1.3 | 4.5 ± 1.2 | NS |
| Systolic BP, mm Hg | 130.8 ± 17.4 | 130.6 ± 17.5 | NS | 131.2 ± 21.2 | 130.8 ± 25.1 | NS |
| Diastolic BP, mm Hg | 81.0 ± 10.7 | 80.8 + 11.7 | NS | 80.4 + 13.3 | 79.8 ± 14.5 | NS |
| Obesity, % | 23.6 | 26.7 | NS | 31.7 | 32.9 | NS |
| Hyperuricemic, % | 0 | 0 | NS | 7.6 | 16.0 | 0.017 |
Data are means ± standard deviation or proportions (%).
↵*Based on ANOVA for continuous variables and chi-square for categorical variables. The rejection level for a null hypothesis was alpha = 0.05 for 2 tails. BMI: body mass index; BP: blood pressure; NS: not significant; HOMA-IR: homeostasis model assessment. To convert to SI units, multiply total cholesterol by 0.0259 (result in mmol/liter), triglycerides by 0.0113 (result in mmol/liter), and uric acid by 59.48 (result in μmol/liter).