Study Type | Disease | No. of Pregnancies | No. of Live Births (%) | No. of Miscarriages (%) | No. of Therapeutic Abortions (%) | Congenital Abnormalities (% of live births) |
---|---|---|---|---|---|---|
TNF inhibitors in general | ||||||
Registry18 | RA | 22 | 20 (91) | 2 (9) | — | 0 |
Registry19,20 | IA | 58 | 30 (52) | 21 (36) | 6 (10) | 4 (7) |
Registry21,22 | IA | 33 | 28 (85) | 4 (12) | 1 (3) | 1 (3) |
Survey23 | IA | 454 | 387 (85) | 25 (6) | 5 (1) | 0 |
Infliximab | ||||||
Case reports24 | CD | 10 | 10 (100) | 0 | 0 | 0 |
Registry25 | CD | 36 | 26 (72) | 5 (14) | 4 (11) | 1 (4) |
Registry26 | CD | 10 | 6 (60) | 3 (30) | 1 (10) | 0 |
Registry27,28 | RA, CD | 627 | 452 (72) | 100 (16) | 72 (11) | 14 (3) |
Etanercept | ||||||
Registry29,30 | RA | 100 | 94 (94) | 6 (6) | 0 | 8 (9) |
Survey31 | RA | 8 | 6 (75) | 1 (13) | 1 (13) | 0 |
Case reports32 | RA, IA | 15 | 12 (80) | 2 (17) | 1 (7) | 0 |
Case reports33 | RA, IA | 5 | 3 (60) | 2 (40) | 0 | 0 |
Adalimumab | ||||||
Registry29,30 | CD, IA | 30 | 27 (90) | 3 (10) | 0 | 2 (7) |
Case report35 | CD | 1 | 1 (100) | 0 | 0 | 0 |
Case report36 | CD | 1 | 1 (100) | 0 | 0 | 0 |
Case report37 | CD | 1 | 1 (100) | 0 | 0 | 0 |
RA: rheumatoid arthritis; IA: inflammatory arthritis; CD: Crohn’s disease.