Potential risk factor that may affect the time to acquisition, persistence, and clearance of HPV infection.
| Preexisting Infections, n = 32 | Incident Infections, n = 68 | ||||||
|---|---|---|---|---|---|---|---|
| Persistence Rate, n (%) | Clearance Rate, n (%) | Time to Clearance, months | Time to Acquisition, months | Persistence Rate, n (%) | Clearance Rate, n (%) | Time to Clearance months | |
| mean (95% CI) | mean (95% CI) | mean (95% CI) | |||||
| Any HPV | 9/32 (28.1) | 29/32 (90.6) | 12.2 (9.4–15.0) | 18.5 (16.8–20.1) | 33/68 (48.5) | 10/68 (14.7) | 17.8 (16.3–19.3) |
| Persistent infection | |||||||
| Yes | — | 6/9 (66.7)* | 23.1 (18.8–27.4)* | — | 1/33 (3.0)* | 20.1 (19.4–20.9)* | |
| No | — | 23/23 (100) | 7.9 (6.7–9.1) | — | 9/35 (25.7) | 13.1 (10.5–15.7) | |
| High-risk infection | |||||||
| Yes | 6/24 (25.0) | 22/24 (91.7) | 11.2 (8.3–14.1) | 20.0 (18.1–21.9)* | 22/46 (47.8) | 6/46 (13.0) | 18.1 (16.3–19.9) |
| No | 3/8 (37.5) | 7/8 (87.5) | 15.1 (8.7–21.6) | 15.2 (12.3–18.2) | 11/22 (50.0) | 4/22 (18.2) | 16.9 (14.4–19.4) |
| Multiple infection | |||||||
| Yes | 7/26 (27) | 24/26 (92.3) | 12.0 (9.0–15.0) | 18.5 (16.7–20.4) | 30/59 (50.8) | 7/59 (11.9) | 18.2 (16.7–19.8) |
| No | 2/6 (33) | 5/6 (83.3) | 12.9 (5.7–20.0) | 17.9 (14.0–21.8) | 3/9 (33.3) | 3/9 (33.3) | 15.5 (11.8–19.3) |
↵* p < 0.05 comparing the clearance rate, time to clearance of HPV infections with and without persistence, and the time to aquisition between high-risk and low-risk HPV infection. For the incident infections, 26/68 (38.2%) infections acquired during the last 2 visits had undetermined outcome. The total number of events for the incident infections equals the sum of the number of infections at the next-to-last or last visit, transient, and persistent infection. Some of the persistent infections can also be cleared. HPV: human papilloma virus.