Table 4.

MCII cutpoints with 2 methodological approaches for changes in health-related quality of life and health status measures after 3 months of DMARD treatment in patients with RA, PsA, and AS.

	75% Sensitivity Cutpoint	80% Specificity Cutpoint	Receiver-operating Characteristic (ROC) Curves
	75% Sensitivity Cutpoint	80% Specificity Cutpoint	Area Under the Curve	95% CI
EQ-5D
RA	0	0.10	0.69	0.65–0.73
PsA	0	0.18	0.68	0.61–0.75
AS	0.04	0.19	0.75	0.68–0.82
SF-6D
RA	0.02	0.08	0.72	0.70–0.74
PsA	0.01	0.07	0.73	0.69–0.76
AS	0.05	0.09	0.77	0.73–0.82
Pain VAS
RA	−4.0	−19.0	0.73	0.71–0.75
PsA	−8.0	−19.0	0.75	0.72–0.79
AS	−15.0	−19.0	0.82	0.78–0.86
Patient global VAS
RA	−6.0	−20.0	0.74	0.72–0.76
PsA	−9.0	−18.0	0.76	0.73–0.79
AS	−16.0	−17.0	0.83	0.79–0.87
MHAQ
RA	0	−0.25	0.71	0.69–0.73
PsA	0	−0.25	0.75	0.72–0.78
AS	−0.13	−0.25	0.75	0.71–0.80

MCII: Minimal Clinically Important Improvement; DMARD: diseasemodifying antirheumatic drug; RA: rheumatoid arthritis; PsA: psoriatic arthritis; AS: ankylosing spondylitis; PASS: Patient Acceptable Symptom State; MHAQ: Modified Health Assessment Questionnaire; VAS: visual analog scale; EQ-5D: EuroQol-5 Dimensions; SF-6D: Short-Form-6 Dimensions.